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Table 2 Comparison of biochemical and haematological measurements before and after antiretroviral treatment

From: Evaluating the utility of early laboratory monitoring of antiretroviral-induced haematological and hepatic toxicity in HIV-infected persons in Cameroon

Laboratory measurements

Pre-ART Mean (SD)

15thDay Post-ART Mean (SD)

Mean Difference (Pre-ART minus Post-ART)

95% CI of mean difference

p-value from paired t-test

ALAT (U/L)

17.87 (20.48)

19.25 (12.01)

−1.37 (23.10)

−5.73-2.99

0.53

ASAT (U/L)

17.32 (11.87)

21.02 (14.12)

−3.70 (16.61)

−6.84- -0.56

0.02

Haemoglobin (g/dl)

10.86 (2.63)

10.36 (1.92)

0.50 (2.29)

0.08-0.92

0.02

Mean cell volume (fl)

79.62 (7.93)

83.49 (9.13)

−3.86 (8.98)

−5.95- -1.78

0.0004

Absolute leucocyte count (10 3 /μl)

6.21 (3.44)

4.84 (1.76)

1.37 (3.62)

0.66-2.09

0.0002

Absolute platelet count (10 5 /μl)

2.72 (1.07)

2.69 (1.14)

0.03 (1.18)

−0.20- 0.25

0.82

  1. ART = antiretroviral therapy, ALAT = alanine aminotransferase, ASAT = aspartate aminotransferase, CI = confidence interval.