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Table 3 Predictors of early liver enzyme elevation and anaemia after two weeks of antiretroviral therapy

From: Evaluating the utility of early laboratory monitoring of antiretroviral-induced haematological and hepatic toxicity in HIV-infected persons in Cameroon

Characteristics

Crude odd ratios (95% Confidence Interval)

p-value

Adjusted odd ratios (95% Confidence Interval)

p-value

Early liver enzyme elevation

NRTI-based regimens

    

AZT-based

1

 

1

 

D4T-based

18.3 (0.91-370.28)

0.058

36.52 (1.44-924.38)

0.029

ABC-based

1

 

1

 

TDF-based

1.83 (0.42-8.07)

0.423

3.43 (0.61-19.21)

0.160

Fasting blood sugar (mg/dl)

    

<126

1

 

1

 

≥126

6.40 (1.02-40.12)

0.047

6.26 (1.00-39.30)

0.50

Early anaemia

Baseline haemoglobin (g/dl)

    

≥10

1

 

1

 

<10

25.6 (8.61-76.17)

<0.0001

60.08 (13.36-270.20)

<0.0001

Body weight (kg)

    

<60

1

 

1

 

≥60

0.32 (0.12-0.88)

0.027

0.28 (0.09-0.83)

0.022

Use of ITN

    

No

1

 

1

 

Yes

4.41 (1.43-13.64)

0.010

4.60 (1.35-15.71)

0.015

NRTI-based regimens

    

AZT-based

1

 

1

 

D4T-based

1

 

1

 

ABC-based

1

 

1

0.252

TDF-based

3.38 (1.56-7.32)

0.002

2.01 (0.61-6.64)

 

Use of haematinics

    

No

1

 

1

 

Yes

3.74 (1.75-8.00)

0.001

1.06 (0.32-3.49)

0.921

Marital status

    

Single

1

 

1

 

Married

0.43 (0.18-0.99)

0.049

0.54 (0.14-2.01)

0.357

Divorced

1

 

1

 

Widowed

0.47 (0.15-1.53)

0.212

0.81 (0.15-4.42)

0.804

  1. ITN = insecticide treated nets, NRTI = nucleotide reverse transcriptase inhibitor, NNRTI = non-nucleotide reverse transcriptase inhibitor, ABC = abacavir, D4T = stavudine, AZT = zidovudine, TDF = tenofovir, EFV = efavirenz, NVP = nevirapine.