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Table 2 Regression coefficients estimating the associations between biomarkers of microbial translocation and inflammation

From: A 12 week longitudinal study of microbial translocation and systemic inflammation in undernourished HIV-infected Zambians initiating antiretroviral therapy

 

Inflammation biomarkers

Microbial translocation biomarkers

C-reactive protein

Soluble CD163

TNF-α receptor 1

Estimate (95% CI)

Estimate (95% CI)

Estimate (95% CI)

p-value; model size

p-value; model size

p-value; model size

Lipopolysaccharide binding protein

28.9 (8.6, 49.1)

169 (−14, 352)

773 (−11, 1559)

p = 0.01; n = 40

p = 0.13; n = 40

p = 0.08; n = 40

Endotoxin core IgM antibody

−25.7 (−42.7, −8.7)

−4.4 (−164, 155)

−713 (−1439, 12)

p = 0.01; n = 38

p = 0.90; n = 38

p = 0.04; n = 40

Endotoxin core IgG antibody

−4.9 (−17.1, 7.4)

39 (−58, 137)

−324 (−762, 113)

p = 0.58; n = 36

p = 0.76; n = 36

p = 0.54; n = 38

Soluble CD14

44.7 (21.3, 68.2)

595 (289, 902)

620 (8, 1232)

p < 0.01; n = 40

p < 0.01; n = 62

p = 0.07; n = 62

Urine lactulose/creatinine ratio (linear)

0.22 (−0.02, 0.45)

11 (−118, 140)

141 (−186, 468)

p = 0.33; n = 27

p = 0.68; n = 38

p = 0.81; n = 39

  1. Results from linear mixed models pooling data across both recruitment and 12 weeks of ART. Models adjusted for age, sex, and baseline CD4+ T-cell count.
  2. Microbial translocation biomarkers (regression predictor) are log-transformed and inflammation biomarkers (regression outcome) remain on the unit scale.
  3. Model size represents total observations (recruitment and 12 week). Bold values represent statistically significant findings.