Table 3 Paired changes in microbial translocation and inflammation biomarkers over 12 weeks of ART
Inflammation biomarkers (12 week change) | |||
|---|---|---|---|
Microbial biomarkers (12 week change) | C-reactive protein | Soluble CD163 | TNF-α receptor 1 |
Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
p-value; model size | p-value; model size | p-value; model size | |
Lipopolysaccharide binding protein | −19 (−72, 33) | 13 (−510, 536) | 757 (−1256, 2769) |
p = 0.45; n = 20 | p = 0.96; n = 20 | p = 0.44; n = 20 | |
Endotoxin core IgM antibody | −18 (−61, 25) | 436 (72, 800) | −74 (−1628, 1480) |
p = 0.38; n = 19 | p = 0.02; n = 19 | p = 0.92; n = 30 | |
Endotoxin core IgG antibody | −1.2 (−34, 31) | 168 (−86, 423) | −500 (−1413, 412) |
p = 0.94; n = 17 | p = 0.18; n = 17 | p = 0.26; n = 18 | |
Soluble CD14 | 38 (7, 69) | 697 (183, 1212) | 553 (−208, 1313) |
p = 0.02; n = 20 | p = 0.01; n = 30 | p = 0.15; n = 20 | |
Urine lactulose/creatinine ratio (linear) | −0.27 (−22, 21) | 154 (−79, 388) | 121 (−86, 329) |
p = 0.97; n = 11 | p = 0.17; n = 14 | p = 0.22; n = 14 | |