Variable | Appropriate initial therapy (n = 187) | Inappropriate initial therapy (n = 72) | P value |
---|---|---|---|
Cultures source, n(%): | Â | Â | Â |
 Blood only | 46 (24.6) | 13 (18.1) | 0.041 |
 BAL | 5 (2.7) | 6 (8.3) |  |
 Sputum | 105 (56.1) | 34 (47.2) |  |
 Tracheal aspirate | 31 (16.6) | 19 (26.4) |  |
Achromobacter species | 0 (0.0) | 1 (1.4) | 0.278 |
Acinetobacter species | 1 (0.5) | 5 (6.9) | 0.007 |
Citrobacter species | 1 (0.5) | 0 (0.0) | 1.000 |
Enterobacter species | 1 (0.5) | 6 (8.3) | 0.002 |
Escherichia coli | 11 (5.9) | 0 (0.0) | 0.038 |
Haemophilus influenzae | 36 (19.3) | 3 (4.2) | 0.002 |
Klebsiella pneumoniae | 7 (3.7) | 1 (1.4) | 0.450 |
Legionella species | 1 (0.5) | 0 (0.0) | 1.000 |
Methicillin-resistant Staphylococcus aureus | 0 (0.0) | 34 (47.2) | <0.001 |
Methicillin-susceptible Staphylococcus aureus | 36 (19.3) | 2 (2.8) | <0.001 |
Moraxella catarrhalis | 5 (2.7) | 0 (0.0) | 0.326 |
Proteus species | 1 (0.5) | 1 (1.4) | 0.479 |
Pseudomonas aeruginosa | 0 (0.0) | 20 (27.8) | <0.001 |
Streptococcus pneumoniae | 79 (42.2) | 3 (4.2) | <0.001 |
Other Streptococci species | 22 (11.8) | 3 (4.2) | 0.097 |
Polymicrobial, n (%): | 14 (7.5) | 5 (6.9) | 0.881 |
Positive blood culture, n (%): | 51 (27.3) | 17 (23.6) | 0.549 |