Table 4 Soluble receptor and IL-1RA concentrations pre-cART and longitudinally over 12 weeks, categorized by neuropathic symptom status
Cytokine | Time point | Time effect | Group effect | |
|---|---|---|---|---|
Median (IQR) (pg/mL) | Neuropathic symptom-group Median (IQR) (pg/mL) | Control group Median (IQR) (pg/mL) | ||
sIL-1RI | Baseline | 29.6 (23.1; 41.0) | 33.3 (23.2; 43.1) | 25.5 (23.0; 34.3) |
Week 2 | 34.0 (26.6; 45.6) | 36.9 (29.0; 48.3) | 33.6 (25.2; 39.5) | |
Week 4 | 37.6 (28.2; 45.6) | 37.5 (27.4; 46.1) | 38.7 (28.9; 42.9) | |
Week 12 | 28.2 (23.4; 38.9) | 34.5 (26.3; 44.2) | 25.2 (22.5; 35.0) | |
sIL-1RII | Baseline | 4572 (1904.5; 6339.5) | 4160.6 (1593.2; 5550.0) | 4922.8 (2017.9; 6489.5) |
Week 2 | 4885.7 (2144.1; 7056.3) | 4744.4 (2144.1; 6174.4) | 4905.8 (2027.0; 8988.9) | |
Week 4 | 5116.7 (2453.1; 7658.8) | 5115.7 (2453.1; 7443.9) | 5751.6 (2674.1; 8659.4) | |
Week 12 | 5806.5 (2726.7; 8628.2) | 5604.6 (2622.7; 8295.6) | 6152.1 (2845.9; 8651.8) | |
sIL-2rα | Baseline | 1102.3 (728.1; 2021.5) | 1068.2 (699.0; 2005.3) | 1210.3 (757.1; 2383.1) |
Week 2 | 1049.2 (595.1; 1781.7) | 1188.4 (638.5; 1831.3) | 866.1 (472.3; 1589.2) | |
Week 4 | 881.2 (580.8; 1763.4) | 745.5 (595.0; 1230.0) | 1032.1 (558.8; 1763.4) | |
Week 12 | 733.3 (434.6; 1073.1) | 647.1 (432.9; 869.5) | 823.8 (610.9; 1264.5) | |
sIL-6R | Baseline | 9379.3 (6441.9; 12912.4) | 9379.3 (6386.6; 12726.3) | 9545.9 (6518.4; 15032.9) |
Week 2 | 9480.6 (7325.3; 14352.6) | 10038.4 (7421.2; 14014.9) | 9183.6 (6446.9; 15126.8) | |
Week 4 | 11538.0 (8288.9; 14148.6) | 11248.9 (7994.0; 12857.9) | 11940.5 (9510.9; 14148.6) | |
Week 12 | 8123.9 (6241.2; 12582.7) | 8250.4 (6978.9; 12582.7) | 7518.7 (5366.6; 11001.6) | |
sTNFRI | Baseline | 536.2 (288.7; 845.4) | 551.4 (292.6; 860.6) | 489.4 (284.7; 749.7) |
Week 2 | 560.9 (347.2; 799.5) | 647.5 (417.4; 803.7) | 516.4 (302.3; 782.2) | |
Week 4 | 606.9 (379.0; 872.3) | 646.0 (424.7; 742.0) | 571.0 (379.0; 913.7) | |
Week 12 | 455.1 (347.2; 750.5) | 532.9 (416.5; 753.8) | 415.2 (319.4; 612.3) | |
sTNFRII | Baseline | 5441.7 (4425.5; 7722.1) | 5441.7 (4285.5; 8470.5) | 5582.4 (4539.0; 7230.2) |
Week 2 | 5104.3 (3728.7; 6909.2) | 5680.6 (4255.6; 7181.9) | 4236.9 (3629.6; 6032.3) | |
Week 4 | 4757.1 (3718.4; 6621.7) | 4307.4 (3531.6; 6486.4) | 5766.0 (4121.2; 6922.4) | |
Week 12 | 4564.9 (3532.0; 6127.8) | 4485.4 (3113.5; 6384.8) | 4579.4 (3924.5; 5791.2) | |
IL-1RA | Baseline | 4.4 (0.0; 16.7) | 10.2 (2.1; 18.8) | 1.9 (0.0; 8.0) |
Week 2 | 3.4 (0.0; 16.7) | 11.3 (0.8; 25.8) | 0.4 (0.0; 14.0) | |
Week 4 | 5.4 (0.0; 13.1) | 5.7 (0.0; 11.5) | 2.1 (0.0; 14.0) | |
Week 12 | 3.4 (0.0; 14.0) | 5.1 (0.8; 15.1) | 0.0 (0.0; 10.2) | |