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Table 1 Annual incidence of patients with each type of invasive pneumococcal disease (IPD), sinusitis, and otitis media at National Taiwan University Hospital from 2000 to 2012

From: Decline in the incidence of invasive pneumococcal disease at a medical center in Taiwan, 2000–2012

Disease Incidence expressed as no. of patients per 10,000 admission (no. of patients) Pvalue
2000 (n = 55920) 2001 (n = 66743) 2002 (n = 62177) 2003 (n = 54574) 2004 (n = 64186) 2005 (n = 67853) 2006 (n = 70814) 2007 (n = 73534) 2008 (n = 74505) 2009 (n = 78756) 2010 (n = 79710) 2011 (n = 81594) 2012 (n = 85253)
IPD 9.8 7.6 8.0 5.9 8.4 4.6 4.0 3.0 4.6 3.6 3.8 3.1 2.1 <0.001
All bacteremia 9.3 7.3 7.1 5.1 7.9 4.1 3.8 2.9 4.2 3.4 3.4 2.7 1.9 <0.001
Primary bacteremia 6.8 4.8 4.2 3.7 5.9 3.8 2.8 2.2 3.4 3.0 2.5 2.0 0.8 <0.001
Bacteremic pneumonia 0.9 1.9 1.6 0.9 1.1 0.3 0.7 0.5 0.4 0.4 0.6 0.4 0.6 <0.001
Empyema 1.3 0.4 1.3 1.1 0.3 0.3 0.3 0.3 0.7 0.1 0.4 0.6 0.7 0.070
Peritonitis 0.4 0.1 0.2 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 < 0.009
Meningitis 0.5 0.3 0.8 0.2 0.9 0.1 0.1 0.0 0.0 0.0 0.3 0.1 0.0 <0.001
Non-IPD               
Pneumonia without bacteremia 16.8 18.4 24.1 19.1 23.2 23.4 27.1 23.0 25.6 22.1 23.5 15.0 12.7 <0.054
Sinusitis 0.2 0.3 0.3 0.2 0.6 0.3 0.3 0.4 0.4 0.0 0.3 0.1 0.2 0.439
Otitis media 0.4 0.3 0.2 0.2 0.5 0.3 0.3 0.4 0.3 0.3 0.0 0.2 0.4 0.69