Table 2 Relative hazards of ALT elevation >200 IU/l from fitting a Cox regression model
Crude and adjusted relative hazards of developing ALT>200 IU/l | ||||||
|---|---|---|---|---|---|---|
Biomarker | Crude RH (95% CI) | p-value | Adjusted*RH (95% CI) | p-value | Adjusted**RH (95% CI) | p-value |
CD8CD38+DR+, % | ||||||
<=48% | 1.0 | 1.0 | 1.0 | |||
>48% | 0.30 (0.03, 2.93) | 0.303 | 0.17 (0.01, 1.91) | 0.150 | 0.09 (0.01, 1.44) | 0.088 |
not measured | 1.24 (0.37, 4.20) | 0.726 | 1.12 (0.32, 3.94) | 0.865 | 0.76 (0.18, 3.27) | 0.711 |
IL-6, pg/ml | ||||||
<=1.1 | 1.0 | 1.0 | 1.0 | |||
>1.1 | 2.77 (0.98, 7.87) | 0.056 | 1.82 (0.61, 5.43) | 0.281 | 1.56 (0.46, 5.32) | 0.481 |
not measured | 2.00 (0.61, 6.57) | 0.251 | 1.79 (0.53, 6.07) | 0.351 | 2.19 (0.18, 27.33) | 0.543 |
LPS, pg/ml | ||||||
<=126 | 1.0 | 1.0 | 1.0 | |||
>126 | 1.26 (0.44, 3.59) | 0.669 | 0.77 (0.21, 2.83) | 0.697 | 0.39 (0.08, 1.84) | 0.235 |
not measured | 0.66 (0.25, 1.78) | 0.417 | 0.67 (0.22, 2.04) | 0.478 | 0.31 (0.08, 1.28) | 0.107 |
sCD14, mg/ml | ||||||
<=3.6 | 1.0 | 1.0 | 1.0 | |||
>3.6 | 0.82 (0.32, 2.07) | 0.669 | 0.79 (0.29, 2.19) | 0.651 | 0.84 (0.25, 2.82) | 0.778 |
not measured | 0.98 (0.33, 2.86) | 0.967 | 1.13 (0.35, 3.59) | 0.842 | 0.80 (0.03, 25.38) | 0.900 |
TNF-alfa, pg/ml | ||||||
<=2.3 | 1.0 | 1.0 | 1.0 | |||
>2.3 | 4.01 (1.32, 12.21) | 0.014 | 2.14 (0.64, 7.15) | 0.217 | 2.03 (0.57, 7.29) | 0.276 |
not measured | 2.48 (0.67, 9.26) | 0.175 | 1.82 (0.46, 7.17) | 0.394 | 1.66 (0.10, 28.78) | 0.728 |