South America map highlighting the Brazilian western Amazon region and HBV and HDV genotypes identified in Amazonas, Acre and Roraima States according to the origin of the participants, indicated by a red star. HDV genotype 3 refers to the 21 isolates sequenced and shown in Figure 1. HBV genotypes are depicted in black and HDV genotype in red. Genotypes are shown according to the origin of participants within subregions of Amazonas State (“Alto Solimões, Jutaí/Solimões/Juruá, Purús, Juruá, Madeira, Alto Rio Negro, Rio Negro/Solimões, Médio Amazonas”). The major hydrographic basins and from the western Amazon are shown including the Negro River/Manaus, Juruá River/Eirunepe and Purús River/ Lábrea. (*) indicates genotypes in other Brazilian states in the north region: Pará, Roraima and Acre.