Table 1 Combined summary of demography and baseline characteristics of the MITT population and early switch subpopulation
MITT population | Early switch subpopulation | |
|---|---|---|
Patient demographics | ||
Number of patients | 250 | 102 |
Female (%) | 115 (46.0) | 49 (48.0) |
Mean age (SD) | 55.4 (16.9) | 53.9 (17.7) |
Median age (range) | 56.0 (19–89) | 53.0 (19–88) |
Race (%) | ||
White | 164 (65.6) | 69 (67.6) |
Black | 52 (20.8) | 28 (27.5) |
Asian | 26 (10.4) | 1 (1.0) |
Other | 8 (3.2) | 4 (3.9) |
Baseline characteristics | ||
Number of patients (%) | 250 (100.0) | 102 (100.0) |
Baseline site of infection (%) | ||
Blood only | 210 (84.0) | 86 (84.3) |
Other sterile site | 38 (15.2) | 16 (15.7) |
Blood and other sterile site | 2 (0.8) | 0 |
APACHE-II score | ||
n (%) | 249 (99.6) | 102 (100.0) |
Mean (SD) | 14.3 (6.7) | 12.7 (6.2) |
Median (range) | 14.0 (2–36) | 12.0 (2–29) |
> 20 (%) | 47 (18.8) | 14 (13.7) |
ANC | ||
n (%) | 227 (90.8) | 93 (91.2) |
≤ 500 cells/mm3 (%) | 9 (3.6) | 2 (2.0) |
Length of ICU stay ≥ 4 days (%)* | 82 (34.3) | 23 (23.5) |
Invasive candidiasis related to IV catheter* | ||
Yes (%) | 104 (45.8) | 44 (46.3) |
All catheters removed within 3 days of therapy? | ||
Yes | 98 (94.2) | 41 (93.2) |
No | 6 (5.8) | 3 (6.8) |
No (%) | 41 (18.1) | 14 (14.7) |
All catheters removed within 3 days of therapy? | ||
Yes | 25 (61.0) | 8 (57.1) |
No | 16 (39.0) | 6 (42.9) |
Baseline isolates of Candida species, n (%) | ||
C. albicans | 112 (44.8) | 46 (45.1) |
C. glabrata | 64 (25.6) | 20 (19.6) |
C. parapsilosis | 41 (16.4) | 20 (19.6) |
C. tropicalis | 27 (10.8) | 11 (10.8) |
C. krusei | 11 (4.4) | 4 (3.9) |
Other | 9 (3.6) | 6 (5.9) |
Most commonly reported comorbidities (terms reported from ≥ 10%), n (%) | ||
Anemia | 127 (50.8) | 58 (56.9) |
Nausea | 70 (28.0) | 29 (28.4) |
Diabetes mellitus | 48 (19.2) | 27 (26.5) |
Hypokalemia | 51 (20.4) | 26 (25.5) |
Malnutrition | 49 (19.6) | 24 (23.5) |