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Table 1 Combined summary of demography and baseline characteristics of the MITT population and early switch subpopulation

From: Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial

  MITT population Early switch subpopulation
Patient demographics  
Number of patients 250 102
Female (%) 115 (46.0) 49 (48.0)
Mean age (SD) 55.4 (16.9) 53.9 (17.7)
Median age (range) 56.0 (19–89) 53.0 (19–88)
Race (%)   
  White 164 (65.6) 69 (67.6)
 Black 52 (20.8) 28 (27.5)
 Asian 26 (10.4) 1 (1.0)
 Other 8 (3.2) 4 (3.9)
Baseline characteristics  
Number of patients (%) 250 (100.0) 102 (100.0)
Baseline site of infection (%)   
 Blood only 210 (84.0) 86 (84.3)
 Other sterile site 38 (15.2) 16 (15.7)
 Blood and other sterile site 2 (0.8) 0
APACHE-II score   
 n (%) 249 (99.6) 102 (100.0)
 Mean (SD) 14.3 (6.7) 12.7 (6.2)
 Median (range) 14.0 (2–36) 12.0 (2–29)
 > 20 (%) 47 (18.8) 14 (13.7)
ANC   
 n (%) 227 (90.8) 93 (91.2)
 ≤ 500 cells/mm3 (%) 9 (3.6) 2 (2.0)
Length of ICU stay ≥ 4 days (%)* 82 (34.3) 23 (23.5)
Invasive candidiasis related to IV catheter*  
 Yes (%) 104 (45.8) 44 (46.3)
   All catheters removed within 3 days of therapy?
    Yes 98 (94.2) 41 (93.2)
    No 6 (5.8) 3 (6.8)
 No (%) 41 (18.1) 14 (14.7)
   All catheters removed within 3 days of therapy?
    Yes 25 (61.0) 8 (57.1)
    No 16 (39.0) 6 (42.9)
Baseline isolates of Candida species, n (%)
C. albicans 112 (44.8) 46 (45.1)
C. glabrata 64 (25.6) 20 (19.6)
C. parapsilosis 41 (16.4) 20 (19.6)
C. tropicalis 27 (10.8) 11 (10.8)
C. krusei 11 (4.4) 4 (3.9)
 Other 9 (3.6) 6 (5.9)
Most commonly reported comorbidities (terms reported from ≥ 10%), n (%)
 Anemia 127 (50.8) 58 (56.9)
 Nausea 70 (28.0) 29 (28.4)
 Diabetes mellitus 48 (19.2) 27 (26.5)
 Hypokalemia 51 (20.4) 26 (25.5)
 Malnutrition 49 (19.6) 24 (23.5)
  1. *Risk factors for invasive candidiasis and catheter management data were systematically collected only after Case Report Form (CRF) revision shortly after study start. Percentages are based on the actual number of patients enrolled in the study after these CRFs were incorporated.
  2. Abbreviations used: ANC, absolute neutrophil count; APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; IV, intravenous; MITT, modified intent-to-treat; SD, standard deviation.