Table 4 Global response rates by baseline pathogen in the MITT population and early switch subpopulation
MITT population | Early switch subpopulation | |||
|---|---|---|---|---|
Baseline pathogen | EOT | EOS | EOT | EOS |
n (%) | n (%) | n (%) | n (%) | |
[95% CI]* | [95% CI]* | [95% CI]* | [95% CI]* | |
C. albicans | ||||
Subjects in analysis | 92 | 84 | 41 | 40 |
Success | 80 (87.0) | 63 (75.0) | 36 (87.8) | 33 (82.5) |
[80.1–93.8] | [65.7–84.3] | [77.8–97.8] | [70.7–94.3] | |
Failure | 12 (13.0) | 21 (25.0) | 5 (12.2) | 7 (17.5) |
C. glabrata | ||||
Subjects in analysis | 52 | 48 | 18 | 17 |
Success | 45 (86.5) | 31 (64.6) | 16 (88.9) | 10 (58.8) |
[77.3–95.8] | [51.1–78.1] | [74.4–100.0] | [35.4–82.2] | |
Failure | 7 (13.5) | 17 (35.4) | 2 (11.1) | 7 (41.2) |
C. parapsilosis | ||||
Subjects in analysis | 34 | 32 | 18 | 18 |
Success | 26 (76.5) | 22 (68.8) | 16 (88.9) | 15 (83.3) |
[62.2–90.7] | [52.7–84.8] | [74.4–100.0] | [66.1–100.0] | |
Failure | 8 (23.5) | 10 (31.3) | 2 (11.1) | 3 (16.7) |
C. tropicalis | ||||
Subjects in analysis | 19 | 17 | 9 | 8 |
Success | 15 (78.9) | 12 (70.6) | 9 (100.0) | 8 (100.0) |
[60.6–97.3] | [48.9–92.2] | [100.0–100.0] | [100.0–100.0] | |
Failure | 4 (21.1) | 5 (29.4) | 0 | 0 |
C. krusei | ||||
Subjects in analysis | 10 | 10 | 3 | 3 |
Success | 6 (60.0) | 5 (50.0) | 3 (100.0) | 3 (100.0) |
[29.6–90.4] | [19.0–81.0] | [100.0–100.0] | [100.0–100.0] | |
Failure | 4 (40.0) | 5 (50.0) | 0 | 0 |