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Table 3 First-line drugs used for treatment of tuberculosis in childhood [1, 9, 12, 13, 24, 2731]

From: Tuberculosis in childhood: a systematic review of national and international guidelines

  Daily dosage (maximum dosage) Twice-thrice weekly dosage (maximum dosage) Adverse Reactions
Isoniazid (INH) 10-15 mg/kg
(300 mg)
20-30 mg/kg
(900 mg)
Hepatotoxic effects , such as mild hepatic enzyme elevation and hepatitis, gastritis, peripheral neuropathy, hypersensitivity
Rifampicin (RIF) 10-20 mg/kg
(600 mg)
10-20 mg/kg
(600 mg)
Orange discoloration of secretions and urine, vomiting, hepatitis, influenza-like reaction, thrombocytopenia
Pyrazinemide (PZA) 30-40 mg/kg
(2 g)
50 mg/kg
(2 g)
Hepatotoxic effects, hyperuricemia, arthralgia, gastrointestinal tract disturbances
Ethambutol (EMB) 15-25 mg/kg
(2,5 g)
50 mg/kg
(2,5 g)
Optic neuritis with decreased red-green colour discrimination and visual acuity, gastrointestinal disturbances, hypersensitivity