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Table 5 Second-line drugs used for TB treatment in children [8, 12, 13, 25, 27, 30, 31]

From: Tuberculosis in childhood: a systematic review of national and international guidelines

  Daily dosage (maximum dosage) Adverse Reactions
Streptomycin 20-40 mg/kg
(1 g)
Auditory, vestibular and renal toxicity, rash
Amikacin
Kanamycin
Capreomycin
15-30 mg/kg
(1 g)
Auditory, vestibular and renal toxicity
Ethionamide 15-20 mg/kg/die, given in 2-3 divided doses
(1 g)
Hepatotoxic effects, gastrointestinal tract disturbances, neurotoxicity, hypersensitivity and hypothyroid
Para-amino salicylic acid 200-300 mg/kg/die, given in 2-4 divided doses
(10 g)
Hepatotoxic effects, gastrointestinal tract disturbances, hypersensitivity
Cycloserine 10-20 mg/kg, given in 2-divided doses
(1 g)
Psychosis, personality changes, seizure, rash
Moxifloxacin 10 mg/kg
(400 mg)
Theoretical effect on growing cartilage, gastrointestinal tract disturbances, rash, headache, restlessness
Levofloxacin 10 mg/kg
(1 g)
 
Linezolid 10 mg/kg
(1,2 g)
gastrointestinal tract disturbances, peripheral neuropathy, thrombocytopenia