Table 5 Second-line drugs used for TB treatment in children [8, 12, 13, 25, 27, 30, 31]
From: Tuberculosis in childhood: a systematic review of national and international guidelines
Daily dosage (maximum dosage) | Adverse Reactions | |
|---|---|---|
Streptomycin | 20-40 mg/kg (1 g) | Auditory, vestibular and renal toxicity, rash |
Amikacin Kanamycin Capreomycin | 15-30 mg/kg (1 g) | Auditory, vestibular and renal toxicity |
Ethionamide | 15-20 mg/kg/die, given in 2-3 divided doses (1 g) | Hepatotoxic effects, gastrointestinal tract disturbances, neurotoxicity, hypersensitivity and hypothyroid |
Para-amino salicylic acid | 200-300 mg/kg/die, given in 2-4 divided doses (10 g) | Hepatotoxic effects, gastrointestinal tract disturbances, hypersensitivity |
Cycloserine | 10-20 mg/kg, given in 2-divided doses (1 g) | Psychosis, personality changes, seizure, rash |
Moxifloxacin | 10 mg/kg (400 mg) | Theoretical effect on growing cartilage, gastrointestinal tract disturbances, rash, headache, restlessness |
Levofloxacin | 10 mg/kg (1 g) | |
Linezolid | 10 mg/kg (1,2 g) | gastrointestinal tract disturbances, peripheral neuropathy, thrombocytopenia |