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Table 1 Descriptive analysis of baseline clinical and therapeutical variables: monoinfected vs coinfected patients.

From: Sustained virological response to peginterferon therapy in patients infected with HCV (genotypes 2 and 3), with or without HIV

Variables HIV- (n = 385) HIV+ (n = 76) OR (95% IC) p-value
Cirrhosis, % (n) 6% (23/385) 31.6 % (24/76) 7.2 (3.7-13.8) <0.0001
HCV-RNA >500.000 IU/ml, % (n) 50.1% (191/381) 35.5 % (27/76) 0.5 (0.3-0.9) 0.02
PegIFN alfa-2b vs alfa-2a, % (n) 15.5% (61/385) 30.3 % (23/76) 2.34 (1.3-4.1) 0.002
PegIFN reduction, % (n) 11.7% (45/385) 5.3 % (4/76) 0.4 (0.1-1.1) 0.09
Stop PegIFN, % (n) 14% (54/385) 30.3 % (23/76) 2.6 (1.5-4.6) 0.0005
RBV reduction, % (n) 14.5% (56/385) 14.5 % (11/76) 0.9 (0.4-1.9) 0.987
Stop RBV, % (n) 9.6% (37/385) 27.6 % (21/76) 3.5 (1.9-6.5) <0.0001
Age >45 years, % (n) 51.9% (200/385) 50% (38/76) 0.92 (0.5-1.5) 0.76
Male gender, % (n) 63.4% (244/385) 82.9 % (63/76) 2.8 (1.5-5.4) 0.009
Genotype 3, % (n) 47% (181/385) 94.7 % (72/76) 20.2 (7.8-66.2) <0.0001
PLT <130,000 cell/mm3, % (n) 7.5% (29/385) 32.9 % (25/76) 6 (3.2-11) <0.0001
HIV RNA <50 cp/ml, % (n)   90.8% (69/76)   
Patients in HAART, % (n)   98.7% (75/76)   
Variables HIV- (n = 385) HIV+ (n = 76)   p -value
ALT, IU/l, mean (DS) 117.6 (111.4) 114.6 (74.7)   0.2126
AST, IU/l, mean (DS) 69.2 (66.3) 74.8 (49.1)   0.0123
BMI, mean (DS) 25.2 (4.2) 23.7 (3.1)   0.006
Cholesterol, mg/dl, mean (DS) 175 (42.7) 150.5 (40)   <0.0001
Triglycerids, mg/dl, mean (DS) 88.8 (43.8) 112.3 (63)   0.001
Age, years, mean (DS) 46.1 (12.3) 44 (5.5)   0.33
Glycemia, mean (DS) 94.4 (19.1) 90.8 (12.2)   0.082
Hb, g/dl, mean (DS) 14.9 (1.5) 14.5 (2.1)   0.095
PT, mean (DS) 103.6 (11.4) 100.5 (13.4)   0.12
Neutrophils, cell/mm3, mean (DS) 3400 (1231) 3080 (1342)   0.014
Weeks of treatment, mean (DS) 19 (8) 41 (17)   <0.0001
Bilirubin, mg/dl, mean (DS) 0.7 (0.4) 1.5 (1.4)   <0.0001
Albumin, g/dl, mean (DS) 4.5 (2.2) 4.4 (0.4)   0.896
CD4+ cell count (cell/mm3), mean (DS)   489 (273)   
Nadir CD4 (cell/mm3), mean (DS)   213 (158)   
  1. PLT, platelets; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, Body Mass Index; Hb, hemoglobin; PT, prothrombin time.