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Table 2 Therapeutic indices of selected tetrapyrroles.

From: Prevention of poxvirus infection by tetrapyrroles

Compound

 

Therapeutic index

 

CC50 (µg/mL)a

WR

IHD-J

IHD-J (EEV)

ZnPPIX

50

3

2

1

CuPcS(3444)

2000

70

140

240

TNapPS4

500

600

700

500

TAnthPS4

50

170

1000

250

TPP[2,6-(OH)2]

50

290

85

71

CuHPIX

500

64

330

460

Co(III)TPP(2,6-F2)S

500

310

1100

82

TPP4OMeS

300

300

230

600

TPP2ClS

1000

1000

1000

1400

TPP2FS

200

150

770

180

  1. aCV-1 cell viability was determined by trypan blue assay as described in Materials and Methods.