Punica granatum(Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide

BMC Infectious Diseases

Table 1 Inhibitory activity of PJ-S21 on infection by primary HIV-1 strains

Primary strain	Subtype, Coreceptor use	ED₅₀* mg/ml	ED₉₀* mg/ml
92RW008	A, R5	0.50 ± 0.05	2.76 ± 0.28
94UG103	A, X4R5	1.42 ± 0.54	3.42 ± 0.98
92US657	B, R5	0.62 ± 0.11	2.86 ± 0.33
93IN101	C, R5	3.56 ± 1.10	8.87 ± 2.55
93MW959	C, R5	1.02 ± 0.19	3.54 ± 0.90
92UG001	D, X4R5	0.62 ± 0.17	2.94 ± 0.85
93THA051	E, X4R5	0.86 ± 0.01	4.09 ± 0.08
93BR020	F, X4R5	4.25 ± 0.78	8.31 ± 1.04
RU570	G, R5	0.42 ± 0.09	1.54 ± 0.16
BCF02	Group O, R5	0.59 ± 0.29	3.92 ± 0.27

* ED₅₀₍₉₀₎ = effective dose(s) of PJ-S21 for 50% (90%) inhibition of infection. One gram of PJ-S21 contains approximately 3.2 mg of the inhibitors adsorbed to starch from pomegranate juice.

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