Table 1 Cultures and histopathology of study groups
Control | G-CSF | Vanco – 25 mg | Vanco 25 mg + G-CSF | Vanco – 50 mg | Vanco – 50 mg + G-CSF | ||
|---|---|---|---|---|---|---|---|
n | n | n | n | n | n | ||
Mice | 15 | 15 | 15 | 15 | 24 | 22 | |
Cultures | Lung | ||||||
no growth | - | 1 | 15 | 15 | 18 | 14 | |
<300 cfu | - | 3 | - | - | - | - | |
>300 cfu | 15 | 11 | - | - | 6 | 8 | |
Liver | |||||||
no growth | - | 1 | 15 | 15 | 17 | 14 | |
<300 cfu | - | 2 | - | - | 1 | - | |
>300 cfu | 15 | 12 | - | - | 6 | 8 | |
Heart | |||||||
no growth | - | 1 | 15 | 15 | 18 | 14 | |
<300 cfu | - | 3 | - | - | - | - | |
>300 cfu | 15 | 11 | - | - | 6 | 8 | |
Spleen | |||||||
no growth | - | - | 13 | 15 | 13 | 12 | |
<300 cfu | - | 1 | - | - | 3 | 2 | |
>300 cfu | 15 | 14 | 2 | - | 8 | 8 | |
Periton | |||||||
no growth | - | 2 | 15 | 15 | 17 | 13 | |
<300 cfu | - | 1 | - | - | 1 | 1 | |
>300 cfu | 15 | 12 | - | - | 6 | 8 | |
Histopathology (inflammation degree) | Lung | ||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | |
+ | 2 | 1 | 5 | 1 | 7 | 9 | |
++ | 7 | 6 | 7 | 6 | 9 | 9 | |
+++ | 5 | 7 | 3 | 7 | 8 | 4 | |
++++ | 1 | 1 | 0 | 1 | 0 | 0 | |
Liver | |||||||
0 | 0 | 0 | 0 | 1 | 1 | 0 | |
+ | 1 | 4 | 7 | 5 | 12 | 5 | |
++ | 7 | 2 | 4 | 5 | 9 | 10 | |
+++ | 4 | 6 | 4 | 4 | 2 | 7 | |
++++ | 3 | 3 | 0 | 0 | 0 | 0 | |
Heart | |||||||
0 | 1 | 0 | 8 | 8 | 10 | 10 | |
+ | 9 | 11 | 7 | 6 | 12 | 7 | |
++ | 5 | 2 | 0 | 1 | 0 | 5 | |
+++ | 0 | 0 | 0 | 0 | 0 | 0 | |
++++ | 0 | 0 | 0 | 0 | 0 | 0 | |
Spleen | |||||||
0 | 0 | 1 | 0 | 0 | 1 | 1 | |
+ | 0 | 2 | 7 | 5 | 13 | 8 | |
++ | 5 | 4 | 7 | 6 | 7 | 8 | |
+++ | 4 | 6 | 1 | 4 | 2 | 5 | |
++++ | 6 | 2 | 0 | 0 | 1 | 0 | |