Table 2 Clinical cure rates at test-of-cure visit
Tigecycline | Imipenem/cilastatin | Difference Tigecycline-Imipenem/cilastatin | Test for Noninferiority | Test for Differences | |||
|---|---|---|---|---|---|---|---|
Population | N | % (95% CI) | N | % (95% CI) | % (95% CI) | P value | |
CE | 282/341 | 82.7 (78.3, 86.6) | 295/351 | 84.0 (79.8, 87.7) | -1 (-7.2, 4.5) | <0.0001 | 0.70 |
Overall | -1 (-6.9, 4.2)* | ||||||
c-mITT | 303/408 | 74.3 (69.7, 78.4) | 317/399 | 79.4 (75.1, 83.3) | -5 (-11.2, 0.0) | <0.0001 | 0.00 |
Overall | -5 (-11.0, 0.0) | ||||||
ME | 199/247 | 80.6 (75.1, 85.3) | 210/255 | 82.4 (77.1, 86.8) | -1.8 (-9.0, 5.4) | 0.0001 | 0.6892 |
Monomicrobial | 80/89 | 89.9 (81.7, 95.3) | 92/104 | 88.5 (80.7, 93.9) | 1.4 (-8.7, 11.0) | ||
Polymicrobial | 119/158 | 75.3 (67.8, 81.8) | 118/151 | 78.1 (70.7, 84.5) | -2.8 (-12.6, 7.1) | ||
Overall | -1.7 (-8.4, 5.1)* | ||||||
m-mITT | 227/309 | 73.5 (68.2, 78.3) | 244/312 | 78.2 (73.2, 82.7) | -4.7 (-11.8, 2.3) | 0.0019 | 0.1976 |
Monomicrobial | 96/121 | 79.3 (71.0, 86.2) | 109/128 | 85.2 (77.8, 90.8) | -5.8 (-15.9, 4.3) | ||
Polymicrobial | 131/188 | 69.7 (62.6, 76.2) | 135/184 | 73.4 (66.4, 79.6) | -3.7 (-13.1, 5.9) | ||
Overall | -4.3 (-11.0, 2.5)* | ||||||