Table 3 Clinical cure rate by baseline diagnosis (ME population) at test-of-cure visit
Tigecycline | Imipenem/cilastatin | Difference Tigecycline-Imipenem/cilastatin | |||
|---|---|---|---|---|---|
Clinical Diagnosis | N | % (95% CI) | N | % (95% CI) | % (95% CI) |
Complicated appendicitis | 128/152 | 84.2 (77.4, 89.6) | 125/145 | 86.2 (79.5, 91.4) | -2.0 (-10.6, 6.7) |
Perforation of the intestines | 13/21 | 61.9 (38.4, 81.9) | 15/23 | 65.2 (42.7, 83.6) | -3.3 (-32.4, 26.2) |
Complicated diverticulitis | 12/17 | 70.6 (44.0, 89.7) | 18/25 | 72.0 (50.6, 87.9) | -1.4 (-32.0, 26.7) |
Intra-abdominal abscess | 11/17 | 64.7 (38.3, 85.8) | 12/17 | 70.6 (44.0, 89.7) | -5.9 (-37.6, 27.4) |
Peritonitis | 12/14 | 85.7 (57.2, 98.2) | 15/16 | 93.8 (69.8, 99.8) | -8.0 (-38.2, 20.5) |
Complicated cholecystitis | 11/12 | 91.7 (61.5, 99.8) | 14/16 | 87.5 (61.7, 98.4) | 4.2 (-29.4, 32.4) |
Gastric and abdominal perforations | 11/13 | 84.6 (54.6, 98.1) | 10/10 | 100.0 (69.2, 100.0) | -15.4 (-46.3, 21.3) |
Other | 1/1 | 100.0 (2.5, 100.0) | 1/3 | 33.3 (0.8, 90.6) | 66.7 (-42.3, 98.2) |
Concomitant bacteremia | 10/14 | 71.4 (41.9, 91.6) | 20/27 | 74.1 (53.7, 88.9) | -2.6 (-35.3, 25.4) |