Table 5 Microbiologic response at the isolate level: selected baseline isolates at test-of-cure visit (ME population)
Tigecycline | Imipenem/cilastatin | |||||
|---|---|---|---|---|---|---|
Isolate | N | MIC90 | % (95% CI) | N | MIC90 | % (95% CI) |
Bacteroides fragilis | 30/43 | 2.0 | 69.8 (53.9, 82.8) | 29/40 | 0.5 | 72.5 (56.1, 85.4) |
Citrobacter spp. | 13/15 | 1.0 | 86.7 (59.5, 98.3) | 5/7 | 0.5 | 71.4 (29.0, 96.3) |
Clostridium spp. | 16/19 | 1.0 | 84.2 (60.4, 96.6) | 14/18 | 2.0 | 77.8 (52.4, 93.6) |
Enterobacter spp. | 6/8 | 1.0 | 75.0 (34.9, 96.8) | 5/10 | 1.0 | 50.0 (18.7, 81.3) |
Enterococcus faecalis (non-VRE) | 10/16 | 0.25 | 62.5 (35.4, 84.8) | 9/18 | 4.0 | 50.0 (26.0, 74.0) |
Escherichia coli | 135/168 | 0.5 | 80.4 (73.5, 86.1) | 152/182 | 0.25 | 83.5 (77.3, 88.6) |
Fusobacterium spp. | 3/5 | 0.25 | 60.0 (14.7, 94.7) | 6/7 | 0.25 | 85.7 (42.1, 99.6) |
Klebsiella spp. | 27/31 | 1.0 | 87.1 (70.2, 96.4) | 36/42 | 0.25 | 85.7 (71.5, 94.6) |
Peptostreptococcus spp. | 6/10 | 0.12 | 60.0 (26.2, 87.8) | 5/8 | 0.25 | 62.5 (24.5, 91.5) |
Proteus spp. | 5/10 | 4.0 | 50.0 (18.7, 81.3) | 3/3 | 4.0 | 100.0 (29.2, 100.0) |
Pseudomonas aeruginosa | 13/18 | 32.0 | 72.2 (46.5, 90.3) | 19/21 | 2.0 | 90.5 (69.6, 98.8) |
Staphylococcus aureus (MRSA) | 1/2 | NA | 50.0 (1.3, 98.7) | 0/1 | NA | 0.0 (0.0, 97.5) |
S. aureus (non-MRSA) | 7/8 | 0.25 | 87.5 (47.3, 99.7) | 3/4 | 0.12 | 75.0 (19.4, 99.4) |
Streptococcus spp. | 63/81 | 0.12 | 77.8 (67.2, 86.3) | 46/67 | 0.12 | 68.7 (56.2, 79.4) |