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Table 6 MIC range, and MIC50 and MIC90 values of selected primary baseline isolates (ME population)

From: A multicenter trial of the efficacy and safety of tigecycline versus imipenem/cilastatin in patients with complicated intra-abdominal infections [Study ID Numbers: 3074A1-301-WW; ClinicalTrials.gov Identifier: NCT00081744]

   Tigecycline Imipenem/Cilastatin
Isolate n MIC range MIC50 MIC90 MIC range MIC50 MIC90
Bacteroides fragilis 83 0.06–16.0 1.0 2.0 0.12–4.0 0.25 0.5
Clostridium perfringens 12 0.06–2.0 1.0 2.0 0.12–0.25 0.12 0.25
Enterococcus faecalis (non-VRE) 32 0.06–0.25 0.12 0.25 1.0–4.0 1.0 4.0
Escherichia coli 350 0.06–1.0 0.25 0.50 0.12–1.0 0.12 0.25
Klebsiella pneumoniae 58 0.25–2.0 0.50 1.00 0.12–0.50 0.25 0.25
Pseudomonas aeruginosa 39 8.0–32.0 16.0 32.0 0.25–4.0 1.0 2.0
Staphylococcus aureus (MRSA) 3 0.12–0.25 NA NA 0.12–32.0 NA NA
S. aureus (non-MRSA) 12 0.12–0.50 0.25 0.25 0.12–0.12 0.12 0.12
  1. NA = MIC50 and MIC90 values are not valid if the number of isolates is less than 10.
  2. MRSA = methicillin-resistant Staphylococcus aureus.
  3. VRE = vancomycin-resistant enterococci.