Figure 1

Course of C. muridarum (MoPn) infection in CD14-/- and wt C57BL/6J mice as assessed by quantitation of viable organisms shed from the urogenital tract. Mouse pneumonitis IFUs were isolated from cervical-vaginal swabs collected at 4, 7, 10 and 14 days and every 7 days thereafter through day 49. Each data point represents the mean (symbol) and standard deviation (vertical line) of IFU observed in HeLa 229 cultures of cervical-vaginal swab material collected from only the culture-positive mice as labeled by group in the chart at that time point based on a Log₁₀ scale. Also, the ratio of culture-positive results out of the total number of mice assessed at each time point is expressed in the table below the chart. A significantly lower IFU count was observed in the CD14-/- group when the course of infection overall was compared by a Kruskal-Wallis analysis of the variance (P < 0.00001). In the table below the chart, by 21 days post-infection more mice resolved infection (culture-negative) beginning day 21 post-infection in the CD14-/- group (P = 0.04, McNemar's chi square analysis with Yates' correction).