Time (hours) after bacterial challenge | A (controls) | B (clarithromycin) | C (amikacin) | D (clarithromycin + amikacin) |
---|---|---|---|---|
Bacteria in blood (Mean ± SE, log10 cfu/ml) | ||||
1.5 | 1.72 ± 0.31 | 2.53 ± 0.61 | 1.92 ± 0.23 | 2.00 ± 0.75 |
3.5 | 1.95 ± 0.26 | 2.05 ± 0.36 | 2.22 ± 0.36 | 1.20 ± 0.20 |
24 | 3.35 ± 1.23 | 4.91 ± 0.99 | 6.24 ± 0.76 | 3.72 ± 0.89 |
48 | 5.93 ± 1.06 | 5.94 ± 1.06 | 5.23 ± 1.77 | 5.13 ± 0.93 |
LPS (Mean ± SE, EU/ml) | ||||
1.5 | 10.79 ± 7.28 | 4.53 ± 1.94 | 10.15 ± 6.87 | 5.88 ± 2.68 |
3.5 | 1.17 ± 0.54 | 6.25 ± 2.94a | 10.02 ± 6.72 | 3.92 ± 0.73 |
24 | 7.35 ± 2.02 | 11.09 ± 4.87 | 9.88 ± 3.72 | 36.22 ± 5.52 |
48 | 21.86 ± 16.42 | 3.00 ± 1.24 | 4.81 ± 2.79 | 8.11 ± 6.97 |
MDA (Mean ± SE, μmol/l) | ||||
0 | 2.56 ± 0.26 | 3.02 ± 0.88 | 2.18 ± 0.78 | 1.50 ± 0.39 |
1.5 | 2.52 ± 1.05 | 4.57 ± 1.33 | 3.48 ± 1.48 | 1.87 ± 0.52 |
3.5 | 3.19 ± 1.06 | 4.54 ± 1.26 | 2.09 ± 1.22 | 1.29 ± 0.26 |
24 | 3.74 ± 1.00 | 1.71 ± 0.73b | 2.72 ± 2.24 | 1.89 ± 0.53 |
48 | 1.75 ± 0.53 | 3.13 ± 1.44 | 3.86 ± 2.79 | 4.77 ± 3.68 |
TNFα (Mean ± SE, pg/ml) | ||||
0 | 18.91 ± 4.95 | 21.98 ± 8.04 | 21.99 ± 4.71 | 22.50 ± 9.09 |
1.5 | 34.53 ± 15.55 | 11.57 ± 0.08 | 40.96 ± 23.29 | 113.67 ± 55.52 |
3.5 | 43.72 ± 27.02 | 17.33 ± 5.82 | 643.85 ± 609.53 | 31.77 ± 20.51 |
24 | 20.81 ± 11.71 | 248.82 ± 226.51 | 29.46 ± 17.96 | 60.49 ± 50.65 |
48 | 977,62 ± 97,63 | 32.81 ± 13.23 | 18.11 ± 6.61 | 47.53 ± 26.46 |