Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women

BMC Infectious Diseases

Table 1 Comparison of HIV-1-Seropositive Women with Low (≤ 85 μg/l) versus Normal (>85 μg/l) Serum Selenium Concentrations.

	Mean (± SD) or Number (%)			Multivariate Logistic Regression¹
	Low serum selenium (n = 104)	Normal serum selenium (n = 296)	p-value²	Adjusted Odds Ratio (95% CI)	p-value
CD4 count (cells/μl)	216 (± 182)	300 (± 210)	<0.001	0.90 (0.77, 1.06)³	0.2
Plasma HIV-1 RNA (log₁₀ of copies/ml)	5.6 (± 0.9)	5.3 (± 1.0)	0.01	0.84 (0.61, 1.17)	0.3
Serum albumin (g/dl)	2.86 (± 0.75)	3.34 (± 0.68)	<0.001	0.93 (0.90, 0.97)	<0.001
Acute phase response⁴	73 (70%)	129 (44%)	<0.001	1.83 (1.05, 3.18)	0.03
HIV-1 symptoms⁵	83 (80%)	198 (67%)	0.008	-	-
HIV-1 signs⁶	34 (33%)	57 (19%)	0.01	-	-
Body mass index (kg/m²)	21.5 (± 3.5)	22.3 (± 4.7)	0.08	-	-

SD – standard deviation; CI – confidence interval
¹ CD4 count, plasma HIV-1 RNA, serum albumin were modeled as continuous variables, and the acute phase response was modeled as a dichotomous variable.
² Calculated by using t-tests for continuous variables and χ² tests for dichotomous variables.
³ Odds ratio is per 100 CD4 cells/μl increase.
⁴ The presence of C-reactive protein ≥ 1 mg/dl and/or α₁-acid glycoprotein ≥ 100 mg/dl.
⁵ Defined as fever for ≥ 1 month, diarrhea for ≥ 1 month, cough for ≥ 1 month, unintended weight loss of ≥ 5 kg during previous year, or itching skin rash during previous year.
⁶ Defined as the presence of oral thrush, oral hairy leukoplakia, oral ulcer, maculopapular rash, or Kaposi's sarcoma.

ISSN: 1471-2334