From: Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospinal fluid
Intracisternal injection (No. of animals) | Bacterial titer in CSF (cfu/ml) | Calorimetric detection time (h)a | Peak heat flow (μW)b | |
---|---|---|---|---|
10 μl CSF | 1 μl CSF | |||
S. pneumoniae (n = 4) | 1.5 ± 0.6 × 108 | 1.5 ± 0.2 | 2.8 ± 0.3 | 342 ± 29 |
N. meningitidis (n = 4) | 1.3 ± 0.3 × 106 | 3.9 ± 0.7 | 5.5 ± 1.1 | 75 ± 24 |
L. monocytogenes (n = 4) | 3.5 ± 2.2 × 104 | 9.1 ± 0.5 | 13.0 ± 1.0 | 340 ± 15 |
Heat-inactivated S. pneumoniae (n = 2) | No growth | Negative | Negative | <10 |
Saline control (n = 2) | No growth | Negative | Negative | <10 |