Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study

BMC Infectious Diseases

Table 3 Relation between markers SLC6a/b and tuberculosis in Chinese stratified by sex and age^a

Alleles/genotypes	TB patients		Control subjects		Odds ratio (95% CI)	Pvalue
Comparison of allele frequencies
*Stratification by sex and age*
Male & age ≤65
G-TGTG	151	(89%)	163	(95%)	1
A- ----	19	(11%)	9	(5%)	2.28 (1.00 – 5.13)	0.0450^b
Female & age ≤65
G-TGTG	47	(78%)	55	(92%)	1
A- ----	13	(22%)	5	(8%)	3.04 (1.01 – 9.16)	0.0408^b
Male & age >65
G-TGTG	201	(82%)	203	(83%)	1
A- ----	43	(18%)	43	(17%)	1.01 (0.63 – 1.61)	0.9668
Female & age >65
G-TGTG	63	(77%)	76	(88%)	1
A- ----	19	(23%)	10	(12%)	2.29 (0.99 – 5.29)	0.0478^b
Comparison of genotype frequencies ^c
*Stratification by sex and age*
Male & age ≤65
G-TGTG/G-TGTG	67	(79%)	79	(92%)	1
A- ----/-	18	(21%)	7	(8%)	3.03 (1.19 – 7.70)	0.0158^b
Female & age ≤65
G-TGTG/G-TGTG	19	(63%)	25	(83%)	1
A- ----/-	11	(37%)	5	(17%)	2.90 (0.86 – 9.75)	0.0798
Male & age >65
G-TGTG/G-TGTG	82	(67%)	82	(67%)	1
A- ----/-	40	(33%)	41	(33%)	0.98 (0.57 – 1.66)	0.9276
Female & age >65
G-TGTG/G-TGTG	24	(59%)	34	(67%)	1
A- ----/-	17	(41%)	17	(33%)	2.68 (1.02 – 7.00)	0.0419^b

^a Markers SLC6a and SLC6b are in perfect LD and thus are analyzed as a single marker (SLC6a/b).
^b Not significant after correction of multiple testing based on false discovery rate at a level of 0.05. For details, see additional file 1.
^c The genotype A- ----/- stands for either A- ----/G-TGTG or A- ----/A- ----.

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