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Table 4 Parasite reduction ratio at 12 and 24 hours: Mixed model results

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

 

12 hr final model

24 hour descriptive model**

24 hr final model

 

%

p-value

N

%

p-value

N

Odds Ratio

p-value

N

Single Rectal Artemisinin or Artesunate vs Parenteral Artemisinins

Parenteral

45.7

 

225

83.8

 

49

  

179

Rectal

59.1

0.018

339

90.0

0.069

331

1.75*

0.072

201

Severe malaria

16.6

0.008

       

Multiple Artesunate vs Single Artesunate

Single artesunate

57.7

 

169

93.7

 

80

  

155

Multiple artesunate

32.7

0.001

249

87.5

0.279

307

0.19

0.004

232

Total dose at 24 hours

19.5

0.011

    

1.14

0.008

 

Single Artemisinin vs Single Artesunate

Single artesunate

64.2*

 

169

93.9

 

46

  

46

Single artemisinin

72.3

0.262

46

95.5

0.792

155

1.13*

0.813

155

Multiple Artemisinin vs Single Artemisinin

Single artemisinin

72.3

 

46

95.5

 

80

  

80

Multiple artemisinin

63.2

0.545

98

89.1

0.348

46

0.60*

0.403

46

Single Artemether vs Single Artesunate

Single artesunate

73.5

 

51

96.7

 

109

  

109

Single artemether

53.5

0.000

124

83.1

0.000

41

0.22*

0.002

41

  1. * No solution was found for the mixed model. Corresponding non-hierarchical regression used instead.
  2. ** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis'