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Table 5 Consolidation treatment used in different clinical studies

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

Initial Treatment group

Consolidation Treatment

Follow-up period

Study Identification/Year of Enrolment (Ref)

Total patients

Artemether ir*, single dose

Artemether ir

7 days

Aceng 2002–3 [32]

51

Artemisinin ir, single dose

Mefloquine + SP

72 hours

Hien 1998

46

Artemisinin ir, multiple dose

Mefloquine

None post discharge

Phuong 1992–5 [31]

46

   

Vinh 1992–4 [33]

52

Artesunate ir, multiple dose

Artesunate + SP

72 hours

Karunajeewa 2003–4 [34]

41

 

Mefloquine

28 days

Looareesuwan 1995 [35]

60

   

Than 1998

100

  

None post discharge

Bhatt 1994–5 [36]

23

 

Chloroquine or SP

None post discharge

Karunajeewa 2001 [37]

48

Artesunate ir, single dose

Artesunate + Mefloquine

28–42 days

Van Vugt 1997–9

44

  

28 days

Looareesuwan 2000

69

 

Mefloquine

28 days

Looareesuwan 1996

26

 

Chloroquine or SP

30 days

Krishna 1996 [10]

23

 

SP

28–42 days

Molyneux 1997–8 [30]

113

 

Mefloquine-SP

72 hours

Hien 1998

44

Artesunate per os

Artesunate + Mefloquine

28–42 days

Van Vugt 1997–9

17

Artemisinins parenteral

Artesunate + SP

72 hours

Karunajeewa 2003–4 [34]

38

 

Mefloquine

28 days

Looareesuwan 1996

24

  

None post discharge

Phuong 1992–5 [31]

40

   

Vinh 1992–4 [33]

123

 

Chloroquine or SP

30 days

Krishna 1996 [10]

11

Quinine parenteral

Quinine

7 days

Aceng 2002–3 [32]

52

 

SP

28–42 days

Barnes 1998 [30]

36

  

None post discharge

Phuong 1992–5 [31]

35

Quinine parenteral + Artesunate ir

SP

42 days

Barnes 1998 [30]

5

Grand Total

   

1167

  1. * ir: Intra-rectal