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Table 2 Treatment outcome and time from start of treatment to conversion of sputum culture among 39 patients with isoniazid-resistant pulmonary tuberculosis

From: Treatment of isoniazid-resistant pulmonary tuberculosis

Treatment regimen

Number of patients

Treatment success

Treatment failure

  

Sputum conversion from positive to negative culture at

 
  

1 month

2 months

3 months

Follow-up sputum sample not available*

 

2HREZ/10RE

Smear-positive (n = 12)

7

1

1

1

2

 

Smear-negative (n = 9)

8

1

-

-

-

2HREZ/4REZ

Smear-positive (n = 9)

6

1

1

-

1

 

Smear-negative (n = 4)

4

-

-

-

-

2HREZ/7RE

Smear-positive (n = 2)

2

-

-

-

-

 

Smear-negative (n = 3)

3

-

-

-

-

Total (n = 39)

 

30

3

2

1

3

  1. * One patient, who was diagnosed as having culture-positive pulmonary tuberculosis based on bronchoscopic examination, could not expectorate sputum after the initiation of treatment. This patient could not expectorate sputum after the initiation of treatment. The radiographic abnormality disappeared completely after the treatment, and this patient was classified as a treatment success.
  2. 2HREZ/10RE: 12-month regimen of rifampin (RIF) and ethambutol (EMB), with pyrazinamide (PZA) during the first 2 months; 2HREZ/4REZ: 6-month regimen of RIF, EMB, and PZA; 2HREZ/7RE: 9-month regimen of RIF and EMB, with PZA during the first 2 months. After drug susceptibility testing confirmed the INH-resistance of the isolated M. tuberculosis strains, INH treatment was discontinued for all the patients.