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Table 1 GenoType® MTBDRplus assay results obtained from sputum smear-positive and smear-negative chronic tuberculosis patients, Burkina Faso

From: Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso

Recruitment (no.)

Smear (no)

GenoType® MTBDRplus

Microbiology

  

MTB Complex result* (%)

DST result

no. (%)

Culture

DST result

no. (%)

M0 (61)

Positive (40)

Positive (32)

MDR

20 (32.8)

MTB Complex

MDR

18 (29.5)

     

MTB Complex

RIF-S, INH-R

2 (3.2)

   

RIF-S, INH-R

3 (4.9)

MTB Complex

RIF-S, INH-R

2 (3.2)

     

Negative

-

1 (1.6)

   

RIF-R, INH-S

1 (1.6)

MTB Complex

MDR

1 (1.6)

   

RIF-S, INH-S

8 (13.1)

MTB Complex

RIF-S, INH-S

7 (11.4)

     

M. simiae

-

1 (1.6)

  

Negative (8)

-

8 (13.1)

M. avium

-

3 (4.9)

     

Other NTM

-

2 (3.2)

     

Negative

-

3 (4.9)

 

Negative (21)

Positive (11)

RIF-S, INH-R

1 (1.6)

Negative

-

1 (1.6)

   

RIF ind, INH-S

1 (1.6)

Negative

-

1 (1.6)

   

RIF-S, INH-S

9 (14.8)

MTB Complex

RIF-S, INH-R

1 (1.6)

     

M. intracellulare

-

1 (1.6)

     

Negative

-

7 (11.4)

  

Negative (10)

-

10 (16.4)

M. avium

-

2 (3.2)

     

M. intracellulare

-

1 (1.6)

     

Negative

-

7 (11.4)

Follow-up (47)

Positive (21)

Positive (14)

MDR

9 (19.1)

MTB Complex

MDR

7 (14.9)

     

MTB Complex

RIF-S, INH-R

1 (2.1)

     

Negative

-

1 (2.1)

   

RIF-R, INH-S

1 (2.1)

MTB Complex

MDR

1 (2.1)

   

RIF-S, INH-R

1 (2.1)

Negative

-

1 (2.1)

   

RIF-S, INH-S

3 (6.4)

MTB Complex

RIF-S, INH-R

1 (2.1)

     

Negative

-

2 (4.3)

  

Negative (6)

-

6 (12.8)

M. avium

-

1 (2.1)

     

M. intracellulare

-

1 (2.1)

     

Other NTM

-

1 (2.1)

     

Negative

-

3 (6.4)

  

Ind (1)

-

1 (2.1)

MTB Complex

RIF-S, INH-S

1 (2.1)

 

Negative (26)

Positive (6)

MDR

1 (2.1)

M. avium

-

1 (2.1)

   

RIF-S, INH-R

1 (2.1)

Nocardia spp.

-

1 (2.1)

   

RIF-S, INH-S

4 (8.5)

Negative

-

4 8.5)

  

Negative (20)

-

20(42.6)

M. avium

-

1 (2.1)

     

Other NTM

-

1 (2.1)

     

Negative

-

18 (38.3)

  1. * MTB Complex, Mycobacterium tuberculosis Complex.
  2. DST, Drug susceptibility testing; MDR, Multidrug-resistant; RIF-S, Rifampin susceptible; RIF-R, Rifampin resistant; INH-S, Isoniazid susceptible; INH-R, Isoniazid resistant; ind, indeterminate
  3. M0, month 0; Follow-up, from month 1 to month 30.