Gene expression profiling of human alveolar macrophages infected by B. anthracisspores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen

Table 2 Ontological clustering of genes upregulated on spore infected cells.¹

Cluster	No. of genes	Annotated genes	Ontology
1	8	BRE, DDIT4, IER3, MCL1, PPP1R15A, SERPINB9, TNFAIP8	Apoptosis
2	8	CCL20, CCL3L1, CCL4L1, CCL5, CXCL2	Chemokine activity
3	37	CXORF43, EGR1, ENO3, ERF, EZH2, FALZ, FLJ25169, FOSL1, GLIS2, HEY1, HIC2, HIVEP2, KLF12, KLF5, LHX3, LOC400713, MYBBP1A, NA, NFATC1, NFE2L2, NR4A2, NR4A3, PCGF3, PNRC1, PROP1, PRRX1, REST, SKIL, THRAP1, ZBTB10, ZFHX4, ZFX, ZNF11B, ZNF586, ZNF587	Transcription
4	4	KRTAP5-5, TCHP	Keratin filament
5	8	IBRDC3, MNAB, PCGF3, REST, RNF17, TAB3, TEX13A, ZNF586	Zinc-finger
6	4	DUSP1, DUSP16, DUSP2, UBLCP1	Protein phosphatase
7	16	BTNL9, CD44, CD6, CXCR6, DRD2, F3, GP1BB, GPR84, GYPA, ICAM1, PCDHA9, PUNC, PVR, SLAMF7, TBXA2R, TNFSF9	Transmembrane
8	4	FAM11A, FLJ37478, MFSD2, REEP5	Transmembrane

¹ Only unique gene names shown in "Annotated genes" column since multiple Affymetrix IDs can map to the same gene name.

ISSN: 1471-2334