Gene expression profiling of human alveolar macrophages infected by B. anthracisspores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen

Table 4 Poorly annotated genes upregulated in spore infected macrophages and their correlation with other conditions.¹

Affymetrix Probe ID	Gene Name	Gene Description	Ratio	Upregulated in	Downregulated in
222068_s_at	LRRC50	leucine rich repeat containing 50	28.7	Lung Cancer (p = 5E-7) [40]; Lung Adenocarcinoma (p = 0.013-0.002) [41, 42]	Squamous Cell Lung Carcinoma (p = 0.006-0.008) [42, 43]
236213_at	LOC100130885	hypothetical protein	29.1	Lung Carcinoma (p = 8.4E-6) [44]
238366_at	MGC33556	hypothetical LOC339541	7.5	Lung Carcinoma (p = 1.3E-6) [40]	Lung carcinoma (p = 1.3E-15) [44]
215971_at		EST	7.5		HPV positive head and neck cancer (p = 6.4E-6) [45] Head and Neck Squamous Cell Carcinoma (p = 1.7E-6) [46]

ISSN: 1471-2334