Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay

BMC Infectious Diseases

Table 2 Markers of infection in the groups with and without proven infection and diagnostic validity

	No proven infection	Proven infection	P	Sens	Spec	PPV	NPV	PLR	AUC
Patient n (%)	23 (46)	27 (54)
WBC count (10⁹/μ) - Median (IQR)	8.4 (3.4)	14.2 (16.3)	0.03	0.66	0.45	0.76	0.62	2.72	0.68
CRP (mg/dl) - Mean (SD)	88.3 (64.0)	122.4 (66.6)	0.07	0.59	0.57	0.62	0.54	1.36	0.65
PCT (mg/L) - Median (IQR)	0.17 (0.39)	1.18 (5.8)	<0.001	0.70	0.73	0.75	0.68	2.62	0.85

CRP cut-off: 100; WBC cut-off: 12,000; PCT cut-off: 0.5
PPV: Positive Predictive Value, NPV: Negative Predictive Value, PLR: Positive Likelihood Ratio, AUC: Area Under Curve, WBC: White Blood Cells, IQR: Interquartile Range, CRP: C- reactive protein, SD: Standard Deviation, PCT: Procalcitonin.

ISSN: 1471-2334