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Table 1 Mean bacterial concentration at time of treatment (0 hours ± SD, pooled data from all three groups), and after 4 or 8 hours of treatment respectively, expressed in log10 cfu/ml.

From: Daptomycin in experimental murine pneumococcal meningitis

Treatment

0 hours

(log10 cfu/ml)

4 hours

(Δlog10 cfu/ml)

8 hours

(Δlog10 cfu/ml)

Dexamethasone

 

-0.02 ± 1.49

1.31 ± 1.16

Dexamethasone/daptomycin*

6.24 ± 0.86

-1.33 ± 1.24

-2.33 ± 1.51

Dexamethasone/vancomycin#

 

-0.43 ± 1.49

-2.82 ± 1.36

  1. *Daptomycin 25 mg/kg intraperitoneally, administered at 0 hours.
  2. #Vancomycin 50 mg/kg intraperitoneally, administered at 0 and 4 hours.