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Table 3 P. falciparum specific immune responses in parasite free individuals and individuals with sub-microscopic parasite densities by 18S QT-NASBA

From: Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparumspecific immune responses in a low endemic area in northern Tanzania

 

Parasite free individuals

Sub-microscopic parasite carriers

p-value

MSP-1 IgG antibodies

   

prevalence, % (n/N)

68.0 (183/269)

76.7 (89/116)

0.086

median level (IQR)

0.26 (0.14 – 0.79)

0.33 (0.18 – 1.17)

0.042

MSP-2 IgG antibodies

   

prevalence, % (n/N)

53.4 (134/251)

58.9 (66/112)

0.33

median level (IQR)

0.32 (0.13 – 0.59)

0.41 (0.19 – 0.72)

0.034

AMA-1 IgG antibodies

   

prevalence, % (n/N)

61.0 (153/251)

65.2 (73/122)

0.44

median level (IQR)

0.34 (0.17 – 0.99)

0.48 (0.21 – 1.04)

0.14

  1. Parasitaemia was detected by 18S QT-NASBA and microscopically confirmed parasite carriers were excluded from this table. The optical density in the ELISA was used as indicator of antibody level. P-values are obtained by χ2-test for antibody prevalence or Wilcoxon Rank-sum test for antibody level. The cut-off values for sero-positivity (antibody prevalence) for MSP-1, MSP-2 and AMA-1 were 0.171, 0.292 and 0.252, respectively.