Table 4 Associations between cervical HPV infection findings and serological reactivity for HPV16

HPV16 DNA

No

398/1593 (20.0)

1.0

1.0

Yes

27/30 (47.4)

3.60 (2.11-6.13)

3.86 (2.23-6.59)

HPV16 DNA

Negative

398/1593 (20.0)

1.0

1.0

Single infection

19/20 (48.7)

3.80 (2.01-7.19)

3.93 (2.07-7.48)

Other types present

8/10 (44.4)

3.20 (1.25-8.17)

3.69 (1.44-9.47)

HPV16 viral load***

Negative

398/1593 (20.0)

1.0

1.0

<1

8/11 (42.1)

2.91 (1.16-7.28)

3.10 (1.23-7.79)

1-100

12/13 (48.0)

4.33 (1.96-9.58)

4.64 (2.09-10.3)

100+

7/6 (53.9)

3.43 (1.14-10.3)

3.73 (1.24-11.2)

HPV18 DNA

No

423/1605 (20.9)

1.0

1.0

Yes

2/18 (10.0)

0.42 (0.10-1.82)

0.45 (0.10-1.96)

HPV31 DNA

No

420/1604 (20.8)

1.0

1.0

Yes

5/19 (20.8)

1.01 (0.37-2.71)

1.18 (0.43-3.21)

HPV33 DNA

No

423/1616 (20.8)

1.0

1.0

Yes

2/7 (22.2)

1.09 (0.23-5.27)

1.13 (0.23-5.52)

HPV6/11 DNA

No

420/1606 (98.9)

1.0

1.0

Yes

5/17 (1.1)

1.12 (0.41-3.06)

1.26 (0.46-3.44)

Non HPV16 Alpha PV 9****

No

400/1574 (20.3)

1.0

1.0

Yes

25/50 (33.3)

2.00 (1.20-3.21)

2.17 (1.32-3.56)

Alpha PV 7

No

412/1566 (20.8)

1.0

1.0

Yes

13/58 (18.3)

0.85 (0.46-1.57)

0.90 (0.49-1.67)

Alpha PV 3/15

No

416/1584 (20.8)

1.0

1.0

Yes

9/40 (18.4)

0.86 (0.41-1.78)

0.87 (0.41-1.81)

Any HPV

No

338/1371 (19.8)

1.0

1.0

Yes

87/252 (25.7)

1.40 (1.07-1.83)

1.52 (1.15-1.83)

Any HPV (non-HPV16)

No

338/1371 (19.8)

1.0

1.0

Yes

60/222 (21.3)

1.10 (0.80-1.49)

1.19 (0.88-1.64)

Any HR-HPV

No

363/1466 (19.9)

1.0

1.0

Yes

62/157 (28.3)

1.60 (1.16-2.19)

1.73 (1.25-2.39)

Any LR-HPV

No

400/1528 (20.8)

1.0

1.0

Yes

25/95 (20.8)

1.00 (0.63-1.58)

1.06 (0.67-1.67)