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Table 5 Univariate analysis of outcome in elderly patients with candidemia

From: The epidemiology, antifungal use and risk factors of death in elderly patients with candidemia: a multicentre retrospective study

Characteristics Non-survivors ( n =20) Survivors ( n =43) p value
Age ≥85 yearsa 4 (20.0) 5 (11.6) 0.619
Male sex 17 (85.0) 34 (79.1) 0.831
Solid tumora 8 (40.0) 7 (16.3) 0.082
Diabetes mellitus 8 (40.0) 16 (37.2) 0.832
Chronic renal failure 9 (45.0) 9 (20.9) 0.049
Prior immunosuppressive drugs 5 (25.0) 11 (25.6) 0.961
Severe hypoalbuminemia 8 (40.0) 5 (11.6) 0.040
Surgerya 5 (25.0) 9 (20.9) 0.971
ICU stay ≥5 days 9 (45.0) 10 (23.3) 0.080
Parental nutrition 7 (35.0) 13 (30.2) 0.705
Receipt of mechanical ventilation 14 (70.0) 13 (30.2) 0.003
CVC placement 9 (45.0) 23 (53.5) 0.530
CVC-related candidemiaa 1 (5.0) 7 (16.3) 0.398
CVC removala 1 (5.0) 13 (30.2) 0.055
Antifungal therapy administered before microbiological documentation 3 (15.0) 19 (44.2) 0.024
 Prophylactic treatmenta 1 (5.0) 6 (14.0) 0.534
 Empiric treatmenta 2 (10.0) 10 (23.3) 0.367
Antifungal therapy administered/changed after microbiological documentation 8 (40.0) 20 (46.5) 0.628
Triazoles usage 9 (45.0) 27 (62.8) 0.184
Echinocandins usage a 2 (10.0) 12 (27.9) 0.206
Absence of antifungal therapies 10 (50.0) 6 (14.0) 0.002
Platelet count ×100 g/L × 109/L 7 (35.0) 5 (11.6) 0.028
Serum creatinine level ≥180 μmol/L 8 (40.0) 7 (16.3) 0.040
Total bilirubin level ≥30 μmol/L 9 (45.0) 7 (16.3) 0.015
Concurrent bacteraemia 6 (30.0) 2 (4.7) 0.016
APACHE II score ≥20 15 (75.0) 16 (37.2) 0.005
Septic shock 13 (65.0) 14 (32.6) 0.015
  1. Data are n (%).
  2. ICU, intensive care unit; CVC, central venous catheter; APACHE, Acute Physiology and Chronic Health Evaluation.
  3. aFisher’s exact test; Unspecified: chi-square test.