Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

Table 4 Two controlled open clinical studies in a total of 148 patients with nitroxoline (NTX) versus norfloxacin (NFX) or cotrimoxazole (CTX); SMX-sulphamethoxazole; TMP-trimethoprim

First author	Year	Pat.(n)	Indication (T/P)	Antibiotic and dosage	Duration	Success rate	Adverse events
Schülke [67]	1986	51 NTX	T: postop., uncompl. UTI	750 mg NTX/d vs. 800 mg NFX/d	3 days	60.8% NTX 59.2% NFX	0%
Schülke [67]	1986	49 NFX	T: postop., uncompl. UTI	750 mg NTX/d vs. 800 mg NFX/d	3 days	60.8% NTX 59.2% NFX	0%
Dodat [68]	1988	48 children	P: postop. UTI (ureteral reflux)	10 mg NTX/kg/d	30–60 days	95% NTX	6% NTX
Dodat [68]	1988	0–8 years	P: postop. UTI (ureteral reflux)	vs. 15 mg SMX/ 3 mg TMP/kg/d	30–60 days	95% CTX	5% CTX

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