Table 2 Sub-analyses of sensitivity and specificity by sample type and smear status
Sample | Statistical model for pooled estimates | Number of studies | Sensitivity | Specificity | ||
|---|---|---|---|---|---|---|
Pooled estimate (95% CI) | Median (IQR) | Pooled estimate (95% CI) | Median (IQR) | |||
CSF | Cannot calculate | 10 |  | 0.85 (0.75 – 1.00) |  | 1.00 (0.98 – 1.00) |
Pleural fluid | Bivariate | 9 | 0.34 (0.24 – 0.44) | 0.37 (0.27 – 0.72) | 0.98 (0.96 – 0.99) | 1.00 (0.98 – 1.00) |
Non-pleural serous fluid | Cannot calculate | 4 |  | 0.67 (Range 0.00 – 1.00) |  | 1.00 (Range 1.00 – 1.00) |
All tissue | Bivariate | 12 | 0.88 (0.77 – 0.95) | 0.90 (0.73 – 0.99) | 0.98 (0.87 – 0.99) | 1.00 (0.89 – 1.00) |
Lymph node biopsy/FNA | Bivariate | 7 | 0.96 (0.72 – 0.99) | 0.97 (0.71 – 1.00) | 0.93 (0.70 – 0.99) | 1.00 (0.94 – 1.00) |
Gastric aspirate | Bivariate | 8 | 0.78 (0.69 – 0.86) | 0.85 (0.74 – 1.00) | 0.99 (0.98 – 0.99) | 1.00 (0.99 – 1.00) |
Smear positive | Random effects | 9 | 0.95 (0.91 – 1.00) | 1.00 (0.98 – 1.00) |  |  |
Smear negative | Random effects | 10 | 0.69 (0.60 – 0.80) | 0.69 (0.61 – 0.83) |  |  |