Autochthonous transmission of Chagas disease in Rio de Janeiro State, Brazil: a clinical and eco-epidemiological study

Table 1 Clinical data of patients Chagas disease (CD), from Rio de Janeiro with autochthonous vectorial transmission

Case	Clinical and laboratory data
Case	Age	Clinical form	Follow-up	IIF	ELISA	ECG	ECO (EF%)	Chest x-ray	Xeno	kDNA PCR	m.exon PCR
1	34	CF	Death	1/320	1/640	PR, PVC	Hypokinesia (45)	Normal	Neg	ND	ND
2	40	CF	Death	1/640	1/1280	RBBB, LAHB, PVC, PAC	Hypokinesia ↑ LA (35)	Cardiomegaly	ND	ND	ND
3	48	CF	Alive	1/1280	RI 4.8	RBBB, LAHB	Normal (75)	Normal	Neg	Neg	Neg
4	65	CF	Death	1/320	1/640	RBBB, LAHB, PVC	Delayed relaxation (60)	Normal	ND	ND	ND
5	49	IF	Alive	1/320	RI 6.6	Normal	PDA (62)	Normal	Neg	Neg	Neg
6	46	CF	Alive	1/640	RI 4.0	RBBB, LAHB	Normal (66)	Normal	Neg	Neg	Neg
7	55	CF	Alive	1/640	RI 5.0	LBBB, PVC	Normal (75)	Normal	Neg	Pos	Neg
8	57	CF/DF	Alive	1/640	RI 4.4	RBBB	Normal (76)	Megaesophagus	Pos	Neg	Neg
9	33	CF	Alive	1/320	RI 5.7	Primary ST-T changes	Hypokinesia ↑ VE (53)	Normal	Neg	Neg	Neg
10	41	IF	Alive	1/40	RI 2.0	Normal	Normal (68)	Normal	Neg	Neg	Neg
11	50	DF	Lost to follow- up	1/40	RI 1.5	Normal	--	Megaesophagus	ND	ND	ND
12	24	IF	Alive	1/80	RI 4.1	Normal	Normal (65)	Normal	Neg	Pos	Pos
13	15	IF	Alive	1/160	RI 6.2	Normal	Normal (67)	Normal	Neg	Pos	Neg
14	34	IF	Alive	1/160	RI 6.4	Normal	Normal (68)	Normal	Neg	Pos	Neg
15	68	CF	Alive	1/80	RI 1.1	RBBB	Delayed relaxation (74)	Cardiomegaly	Neg	Neg	Neg

CF = cardiac form, DF = digestive form, ECG = electrocardiography; ECO = echocardiography, EF = ejection fraction, ELISA = enzyme-linked immunosorbent assay, IF = indeterminate form, IIF = indirect immunofluorescence, kDNA = kinetoplast DNA, LA = left atrium, LAHB = left anterior hemiblock, LBBB = left bundle branch block, LV = left ventricle, m.exon = mini-exon multiplex, ND = not determined; PAC = premature atrial complex, PCR = polymerase chain reaction, PDA = patent ductus arteriosus, PVC = premature ventricular complex, PR = pacemaker rhythm, x –ray = radiograph, RBBB = right bundle branch block, RI = reactivity index.
The ages described are from the beginning of the patients’ follow-up at our outpatient service. Except for cases 1, 2 and 4 who died before the start of this study, all clinical and laboratory data were reevaluated to check for serological and molecular diagnosis and the clinical form presentation. All patients presented negative hemoculture for T. cruzi.

ISSN: 1471-2334