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Table 2 Bacterial findings and contribution of different methods to diagnostic yield in the study population

From: Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway

Pathogen

No. (%) of patients with positive findings(n = 267)

Blood culture(n = 267)

Pleural fluid culture(n = 14)

Urinary antigen test(n = 262)

BAL(n = 8)

Sputum sample for culture and/orL. pneumophilaPCR(n = 165)a

NP swab culture(n = 263)

PCR

Serology(n = 263)

NP swab(n = 262)b

OP swab(n = 262)c

Streptococcus pneumoniae

81 (30)

21

-

24

-

4

10

6

16

NA

Bordetella pertussis

15 (6)

NA

NA

NA

NA

NA

NA

-

-

15

Haemophilus influenzae

14 (5)

1

-

NA

-

5

8

NA

NA

NA

Mycoplasma pneumoniae

10 (4)

NA

NA

NA

NA

NA

NA

7

1

2

Chlamydophila pneumoniae

7 (3)

NA

NA

NA

NA

NA

NA

-

2

5

Legionella pneumophila

7 (3)

NA

NA

7

NA

-

NA

NA

NA

NA

Enterobacteriaceae d

6 (2)

2

-

NA

-

3

1

NA

NA

NA

Moraxella catarrhalis

5 (2)

-

-

NA

-

2

3

NA

NA

NA

Miscellaneous e

3 (1)

1

1

NA

-

-

1

NA

NA

NA

Haemophilus parainfluenzae

2 (1)

1

-

NA

-

1

-

NA

NA

NA

Totalf

126 (47)

26

1

31

-

15

23

13

19

22

  1. Note: Data are number of patients, unless otherwise stated, whose infections were etiologically established by use of a particular method listed in descending order of specificity (NP vs. OP swab PCR depends on pathogen tested). Additional patients had etiology established by use of different methods; e.g., S. pneumoniae infection was established by use of urinary antigen test in 24 additional patients whose etiology was not established by use of blood culture etc. PCR: S. pneumoniae was detected by use of qPCR; and L. pneumophila, M. pneumoniae, C. pneumoniae and B. pertussis by use of real-time PCR. BAL, bronchoalveolar lavage; qPCR, real-time quantitative polymerase chain reaction; NP, nasopharynx; OP, oropharynx; NA, not applicable.
  2. aOf 165 sputum samples, 73 were of good quality. One of these tested positive for L. pneumophila by use of real-time PCR (urinary antigen test in this case was also positive).
  3. bOf 262 patient samples, 240 revealed valid results for qPCR detection of S. pneumoniae, and 259 for real-time PCR detection of M. pneumoniae, C. pneumoniae and B. pertussis.
  4. cOf 262 patient samples, 238 revealed valid results for qPCR detection of S. pneumoniae, and 259 for real-time PCR detection of M. pneumoniae, C. pneumoniae and B. pertussis.
  5. dInclude either of the following: E. coli, P. aeruginosa or Enterobacter species.
  6. eBlood culture, Group A streptococcus; Pleural fluid culture, Prevotella spp. and Dialister pneumosintes (isolated from the same patient); NP swab culture, Group A streptococcus.
  7. fNo. of patients does not add up to no. of pathogens because some patients had multiple pathogens detected: a total of 150 bacteria were detected in 126 patients.