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Table 1 Serotype-specific Streptococcus pneumoniae Immunoglobulin G titres (IgG) in an adult with previously unknown hyposplenia suffering from recurrent episodes of invasive pneumococcal disease (IPD)

From: Recurrent severe invasive pneumococcal disease in an adult with previously unknown hyposplenia

IPD event, serotype

Date

Serotype,μg/ml #

  

1

3

4

5

6B

7F

9V

12F MFI

14

17F MFI

18C

19A

19F

23F

1 st IPD, day 5, 7F

17.08.2008

0.91

0.09

0.20

<0.02

0.58

0.13

0.47

239.5

2.97

281,3

1.06

0.67

0.85

1.72

1 st IPD, day 20, 7F

02.09.2008

1.00

0.09

0.23

<0.02

0.59

0.17

0.50

250.3

2.73

295.5

0.86

0.77

1.55

1.75

2 nd IPD, day 16, 17F

29.07.2012

2.81

0.38

0.49

0.94

2.54

1.23

3.07

387.8

3.49

367.5

2.58

3.14

3.97

5.35

PCV13 immunization

13.09.2012

**

**

**

**

**

**

**

 

**

 

**

**

**

**

Post-immunization*

30.10.2012

5.62

0.57

0.21

0.41

6.02

0.42

5.02

n/a

33.24

n/a

12.32

1.99

2.67

2.48

3 rd IPD, day 3, 17F

06.01.2013

3.23

0.20

0.12

0.18

2.00

0.18

2.05

174.5

15.52

198.5

3.84

0.82

0.97

1.31

  1. #, Blood samples were analyzed for antigen-specific IgG-titers against 14 different pneumococcal serotypes measured by a Luminex xMAP microsphere-based liquid array modified from Pickering et al. [Pickering JW, Hill HR. Measurement of antibodies to pneumococcal polysaccharides with luminex xMAP microsphere-based liquid arrays. Methods Mol Biol. 2012;808:361–75]. The type-specific protective IgG-titers are unknown. Levels beneath 0.35 μg/ml are marked with bold as studies suggest that titers above 0.35 μg/ml provide protection against invasive pneumococcal disease after vaccination with a conjugated vaccine. IgG-titers are listed in μg/ml based on the 89SF international standard, except 12 F and 17 F, which are listed in mean fluorescence intensity (MFI) because a reference material were not available.
  2. *Average of two measurements on the same sample.
  3. **, Serotypes covered by the PCV13 vaccine.
  4. n/a, not available.