From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era
Serotype | Age group | Pre-vaccination (1992-2006) | Early vaccination (PCV7) (2007-2010) | Late vaccination (PCV13) (2010-2014) | Pre-vaccination vs. Early vaccination | Early vaccination vs. Late vaccination | |||
---|---|---|---|---|---|---|---|---|---|
n= | % | n= | % | n= | % | p value | p value | ||
PCV7 | children | 1,282 | 61.8 | 169 | 23.5 | 40 | 5.2 | 1,30E-72 | 4,59E-25 |
non-PCV7 | children | 793 | 38.2 | 551 | 76.5 | 724 | 94.8 | Â | Â |
all | children | 2,075 | 100.0 | 720 | 100.0 | 764 | 100.0 | Â | Â |
PCV7 | adults | 1,943 | 43.4 | 1,426 | 24.7 | 711 | 8.2 | 3.78E-88 | 5.97E-161 |
non-PCV7 | adults | 2,534 | 56.6 | 4,338 | 75.3 | 7,925 | 91.8 | Â | Â |
all | adults | 4,477 | 100.0 | 5,764 | 100.0 | 8,636 | 100.0 | Â | Â |
PCV7 | all | 3,225 | 49.2 | 1,595 | 24.6 | 751 | 8.0 | 4.39E-189 | 2.06E-182 |
non-PCV7 | all | 3,327 | 50.8 | 4,889 | 75.4 | 8,649 | 92.0 | Â | Â |
all | all | 6,552 | 100.0 | 6,484 | 100.0 | 9,400 | 100.0 | Â | Â |
PCV13 | children | 1,751 | 84.4 | 506 | 70.3 | 312 | 40.8 | 1.50E-15 | 1.96E-30 |
non-PCV13 | children | 324 | 15.6 | 214 | 29.7 | 452 | 59.2 | Â | Â |
all | children | 2,075 | 100.0 | 720 | 100.0 | 764 | 100.0 | Â | Â |
PCV13 | adults | 3,238 | 72.3 | 3,839 | 66.6 | 4,086 | 47.3 | 5.24E-10 | 1.90E-116 |
non-PCV13 | adults | 1,239 | 27.7 | 1,925 | 33.4 | 4,550 | 52.7 | Â | Â |
all | adults | 4,477 | 100.0 | 5,764 | 100.0 | 8,636 | 100.0 | Â | Â |
PCV13 | all | 4,989 | 76.1 | 4,345 | 67.0 | 4,398 | 46.8 | 5.55E-31 | 9.74E-142 |
non-PCV13 | all | 1,563 | 23.9 | 2,139 | 33.0 | 5,002 | 53.2 | Â | Â |
all | all | 6,552 | 100.0 | 6,484 | 100.0 | 9,400 | 100.0 | Â | Â |
23A | all | 37 | 0.6 | 101 | 1.6 | 225 | 2.4 | 2.45E-08 | 2.57E-04 |
23B | all | 10 | 0.2 | 34 | 0.5 | 265 | 2.8 | 2.26E-04 | 1.55E-29 |
23F | all | 407 | 6.2 | 205 | 3.2 | 93 | 1.0 | 1.36E-16 | 1.29E-22 |
15A | all | 45 | 0.7 | 35 | 0.5 | 226 | 2.4 | 3.13E-01 | 3.14E-22 |
15B | all | 38 | 0.6 | 79 | 1.2 | 120 | 1.3 | 1.22E-04 | 7.72E-01 |
15C | all | 33 | 0.5 | 41 | 0.6 | 105 | 1.1 | 3.52E-01 | 1.66E-03 |
15B/C | all | 71 | 1.1 | 120 | 1.9 | 225 | 2.4 | 1.25E-01 | 6.55E-01 |
15F | all | 6 | 0.1 | 1 | 0.0 | 4 | 0.0 | 3.31E-04 | 2.31E-02 |