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Table 1 Effects of PCV7 and PCV13 vaccination on IPD among children (0-15 years) and adults (≥16 years) in Germany

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

Serotype

Age group

Pre-vaccination (1992-2006)

Early vaccination (PCV7) (2007-2010)

Late vaccination (PCV13) (2010-2014)

Pre-vaccination vs. Early vaccination

Early vaccination vs. Late vaccination

n=

%

n=

%

n=

%

p value

p value

PCV7

children

1,282

61.8

169

23.5

40

5.2

1,30E-72

4,59E-25

non-PCV7

children

793

38.2

551

76.5

724

94.8

  

all

children

2,075

100.0

720

100.0

764

100.0

  

PCV7

adults

1,943

43.4

1,426

24.7

711

8.2

3.78E-88

5.97E-161

non-PCV7

adults

2,534

56.6

4,338

75.3

7,925

91.8

  

all

adults

4,477

100.0

5,764

100.0

8,636

100.0

  

PCV7

all

3,225

49.2

1,595

24.6

751

8.0

4.39E-189

2.06E-182

non-PCV7

all

3,327

50.8

4,889

75.4

8,649

92.0

  

all

all

6,552

100.0

6,484

100.0

9,400

100.0

  

PCV13

children

1,751

84.4

506

70.3

312

40.8

1.50E-15

1.96E-30

non-PCV13

children

324

15.6

214

29.7

452

59.2

  

all

children

2,075

100.0

720

100.0

764

100.0

  

PCV13

adults

3,238

72.3

3,839

66.6

4,086

47.3

5.24E-10

1.90E-116

non-PCV13

adults

1,239

27.7

1,925

33.4

4,550

52.7

  

all

adults

4,477

100.0

5,764

100.0

8,636

100.0

  

PCV13

all

4,989

76.1

4,345

67.0

4,398

46.8

5.55E-31

9.74E-142

non-PCV13

all

1,563

23.9

2,139

33.0

5,002

53.2

  

all

all

6,552

100.0

6,484

100.0

9,400

100.0

  

23A

all

37

0.6

101

1.6

225

2.4

2.45E-08

2.57E-04

23B

all

10

0.2

34

0.5

265

2.8

2.26E-04

1.55E-29

23F

all

407

6.2

205

3.2

93

1.0

1.36E-16

1.29E-22

15A

all

45

0.7

35

0.5

226

2.4

3.13E-01

3.14E-22

15B

all

38

0.6

79

1.2

120

1.3

1.22E-04

7.72E-01

15C

all

33

0.5

41

0.6

105

1.1

3.52E-01

1.66E-03

15B/C

all

71

1.1

120

1.9

225

2.4

1.25E-01

6.55E-01

15F

all

6

0.1

1

0.0

4

0.0

3.31E-04

2.31E-02

  1. The pneumococcal season 2006-2007 in which childhood pneumococcal conjugate vaccination was introduced was considered a transition period and left out of the analysis. P-values reaching statistical significance are depicted in bold.