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Table 4 Multi locus sequence types of serotype 15A (n = 20) and serotype 23B (n = 21) isolates, with their year of isolation and MIC towards penicillin

From: Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era

serotype

MLST

CC

aroE

gdh

gki

recP

Spi

xpt

ddl

n=

years

MIC PEN

23B

439

439

1

8

9

2

6

4

6

7

1994,1998, 2001, 2007, 2008, 2009, 2010

0.015 (n = 7)

23B

9867

439

1

4

388

2

6

4

6

3

2012, 2013, 2014

0.015 (n = 3)

23B

9872

439

1

8

421

2

6

4

6

1

2003

0.015

23B

778

439

1

8

9

1

6

1

6

1

2006

0.015

23B

1349

338

18

13

8

6

3

6

8

6

1997, 2001, 2004, 2009, 2010, 2012

0.06; 0.12; 0.25 (n = 3); 0.5

23B

2372

338

18

13

8

6

3

6

46

3

2008, 2011 (n = 2)

0.015; 0.12; 0.25

15A

63

63

2

5

36

12

17

21

14

5

1998, 2001, 2006, 2008, 2009

0.06; 0.12 (n = 2); 0.25; 0.5

15A

2105

63

2

5

36

12

17

21

4

2

2010, 2013

1 (n = 2)

15A

2613

63

2

5

36

12

17

1

4

1

2013

2

15A

9874

63

2

5

422

12

17

21

14

1

2004

0.25

15A

3811

156

7

11

10

1

6

8

315

2

2013, 2014

0.015 (n = 2)

15A

9868

156

7

33

1

1

6

31

14

1

1999

0.015

15A

473

473

7

25

4

4

15

20

28

1

2002

0.015

15A

9873

473

7

25

4

4

15

20

623

1

2011

0.015

15A

410

193

8

10

2

16

7

26

1

1

2009

0.015

15A

199

199

8

13

14

4

17

4

14

1

2005

0.015

15A

1576

292

10

8

8

8

6

28

14

1

1998

0.12

15A

9308

group of three

15

5

15

1

398

1

18

1

2004

0.015

15A

9871

singleton

7

424

8

8

6

570

14

1

2012

0.015

15A

1577

singleton

10

13

67

16

6

1

8

1

1999

0.25

  1. CC: clonal complex.
  2. MLST in bold are new sequence types found for the first time in this study.