Table 5 Association of IL-23R polymorphisms and drug-sensitivity and conversion of sputum culture in pulmonary TB patients
dbSNP ID/ | Genotype | Drug-sensitivity (N = 250) | OR (95 % CI) | Months of treatment for Negative culture (N =250) | OR (95 % CI) | ||
|---|---|---|---|---|---|---|---|
CNV |  | Drug-sensitive | Drug-resistant |  | ≤2 months | > 2 months |  |
|  |  | N = 172 n (%) | N = 78 n (%) |  | N = 195 n (%) | N = 55 n (%) |  |
rs1884444 | TT | 72 (41.9) | 31 (39.7) | 1 | 79 (40.5) | 24 (43.6) | 1 |
|  | GG + GT | 100 (58.1) | 47 (60.3) | 1.09 (0.63–1.88) | 116 (59.5) | 31 (56.4) | 0.88 (0.48–1.61) |
rs10889664 | CC | 85 (49.4) | 38 (48.7) | 1 | 96 (49.2) | 27 (49.1) | 1 |
|  | TT + CT | 87 (50.6) | 40 (51.3) | 1.03 (0.60–1.76) | 99 (50.8) | 28 (50.9) | 1.01 (0.55–1.83) |
rs11465788 | TT | 73 (42.1) | 32 (41.0) | 1 | 83 (42.6) | 22 (40.0) | 1 |
|  | CC + CT | 99 (57.9) | 46 (59.0) | 1.06 (0.62–1.83) | 112 (57.4) | 33 (60.0) | 1.11 (0.60–2.05) |
rs7518660 | GG | 8 (4.7) | 4 (5.1) | 1 | 9 (4.6) | 3 (5.5) | 1 |
|  | AA + AG | 164 (95.3) | 74 (94.9) | 0.90 (0.29–3.09) | 186 (95.4) | 52 (94.5) | 0.84 (0.22–3.21) |
rs11465802 | CC | 117 (32.0) | 31 (60.3) | 1 | 116 (59.5) | 32 (58.2) | 1 |
|  | AA + AC | 55 (68.0) | 47 (39.7) | 3.23 (1.85–5.62) | 79 (40.5) | 23 (41.8) | 1.06 (0.58–1.94) |
rs10889677 | AA | 37 (21.5) | 16 (20.5) | 1 | 41 (21.0) | 12 (21.8) | 1 |
|  | CC + AC | 135 (78.5) | 62 (79.5) | 1.06 (0.55–2.05) | 154 (79.0) | 43 (78.2) | 0.95 (0.46–1.97) |
CNV | CN = 2 | 138 (80.2) | 62 (79.5) | 1 | 157 (80.5) | 43 (78.2) | 1 |
|  | CN = 1, 3, 4 | 34 (19.8) | 16 (20.5) | 1.05 (0.54–2.04) | 38 (19.5) | 12 (21.8) | 1.15 (0.56–2.40) |