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Table 1 Patients characteristics and clinical outcome

From: Epidemic spread of Pandoraea pulmonicola in a cystic fibrosis center

  

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

Age (years)

 

64

23

39

29

18

18

Sex

 

M

M

M

F

M

M

CFTR mutation

 

1717-1GA/2789 + 5GA

F508del/F508del

F508del/F508del

F508del/F508del

F508del/R553X

F508del/F508del

Date of first P. pulmonicola isolation

 

2000

March 2009

June 2009

October 2009

November 2009

December 2009

Associated pathogens

 

mucoid P. aeruginosa

mucoid P. aeruginosa

mucoid P. aeruginosa

mucoid P. aeruginosa

S. aureus, mucoid. P. aeruginosa, A. xylosoxidans, A. fumigatus

S. aureus, mucoid P. aeruginosa, A. fumigatus, G. argillacea

Best Forced Expiratory Volume in 1 second (FEV1) value per year

2009

25

45

33

43

47

61

 

2010

/

41

25

35

44

42

 

2011

/

40

20

/

42

41

 

2012

/

31

19

/

/

59

 

2013

/

42

19

/

/

60

Number of intravenous antibiotic courses per year

2009

8

2

6

10

7

8

 

2010

/

3

5

3

8

5

 

2011

/

1

4

/

7

6

 

2012

/

3

6

/

/

1

 

2013

/

0

3

/

/

0

Organ transplantation

 

No

No

No (listed for heart and lung transplantation)

Lung transplantation (March 2010)

Lung and liver transplantation (April 2012)

Lung transplantation (January 2012)

Clinical outcome

 

Death (October 2009) from severe comorbidities

Stable

Decline in lung function

Death (April 2010) from post transplantation bacteremia due to P. aeruginosa

Death (May 2012) from severe multiple post transplantation organ failure

Stable