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Table 1 DAVID Functional annotation clustering of genes that were down-regulated in M. tuberculosis exposed to PZA under different growth rates in early and late recovery

From: The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?

  

Slow growth (69.3 h MGT)

Fast growth (23.1 h MGT)

  

Down-regulated in early recovery

Down-regulated in late recovery

Down-regulated in early recovery

Down-regulated in late recovery

Annotation scheme

Annotation

Count

Bonferroni corrected EASE-value

Count

Bonferroni corrected EASE-value

Count

Bonferroni corrected EASE-value

Count

Bonferroni corrected EASE-value

KEGG_PATHWAY

ribosome

25

4.00E-24

28

1.70E-26

n/a

n/a

7

4.20E-08

GOTERM_MF_FAT

structural constituent of ribosome

25

1.60E-21

28

4.10E-25

n/a

n/a

7

1.10E-08

SP_PIR_KEYWORDS

ribonucleoprotein

25

3.60E-21

28

3.40E-24

n/a

n/a

7

1.90E-06

GOTERM_MF_FAT

rRNA-binding

21

1.00E-20

23

2.30E-23

n/a

n/a

4

1.10E-03

SP_PIR_KEYWORDS

rRNA-binding

21

7.80E-21

23

4.30E-23

n/a

n/a

4

8.10E-03

SP_PIR_KEYWORDS

ribosomal protein

25

3.50E-20

28

5.00E-23

n/a

n/a

7

3.10E-06

GOTERM_MF_FAT

structural molecule activity

25

5.50E-20

28

2.60E-23

n/a

n/a

7

2.50E-08

GOTERM_CC_FAT

ribosome

25

2.50E-19

28

1.30E-21

n/a

n/a

7

9.80E-05

GOTERM_CC_FAT

ribonucleoprotein complex

25

8.80E-19

28

5.60E-21

n/a

n/a

7

1.30E-04

GOTERM_BP_FAT

translation

29

1.10E-17

32

1.00E-19

n/a

n/a

7

9.20E-06

SP_PIR_KEYWORDS

RNA-binding

22

7.50E-16

25

1.50E-18

n/a

n/a

4

4.50E-02

GOTERM_MF_FAT

RNA binding

26

1.80E-14

27

1.80E-14

n/a

n/a

5

1.50E-03

GOTERM_CC_FAT

ribosomal subunit

10

8.60E-09

10

3.60E-08

n/a

n/a

4

3.20E-03

  1. A corrected EASE-value of 0.01 and minimum gene number per category of five was used to perform functional annotation clustering on all down-regulated genes in the early recovery phase (4 h after the addition of 100 μgml−1 PZA) or the late recovery phase (2 MGT after the addition of 100 μgml−1 PZA) compared to the pre-PZA phase