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Table 6 Grading of body of evidence for effectiveness of other interventions. Question: Do interventions (other than short treatment, incentives or social intervention) result in higher initiation, adherence, or completion rates than usual care in individuals eligible for LTBI treatment?

From: Interventions for improving adherence to treatment for latent tuberculosis infection: a systematic review

   

Quality assessment

n/N = %

Effect

Quality

Importance

No of studies (No of participants)

Design

Population treatment interventiona

Risk of bias

Inconsistency

Indirectness

Imprecision

Other considerations

Other intervention

OR (95 % CI)

Absolutea (per 1000 (95 % CI))

Usual care

Initiation

1 (107) [59]

Observational study

Healthcare workers H

Not seriousb

Not serious

Not serious

Seriousc

 

32/62 = 52 %

8.8 (3.1–23)

413 (168–631)

⊕OOO Very low

Critical

Use of IGRAs

5/45 = 11 %

Adherence

0 (0)

No evidence available

–

–

–

–

–

–

–

–

–

–

Critical

Completion

0 (0)

No evidence available

–

–

–

–

–

–

–

–

–

–

Critical

  1. Bibliography: Sahni et al. 2009 [59]
  2. n/N No of individuals with LTBI who initiated, or adhered to or completed treatment/total number of subjects; CI confidence interval; IGRAs Interferon Gamma Release Assay; OR odds ratio; PWID people who inject drugs; RCT randomised controlled trial
  3. aCalculated via GradePro
  4. bUse of unvalidated patient-reported outcomes (telephone interview)
  5. cTotal number of events <125