Initiation and completion rates for latent tuberculosis infection treatment: a systematic review

Sandgren, Andreas; Vonk Noordegraaf-Schouten, Marije; van Kessel, Femke; Stuurman, Anke; Oordt-Speets, Anouk; van der Werf, Marieke J.

doi:10.1186/s12879-016-1550-y

BMC Infectious Diseases

Table 1 Number of included studies and ranges of initiation and completion rates per study population

From: Initiation and completion rates for latent tuberculosis infection treatment: a systematic review

Study population	Short treatment regimens		Long treatment regimens		Short/long treatment regimens combined
	n	Range rates (%)	n	Range rates (%)	n	Range rates (%)	N
Initiation rates
Prospective studies (n = 20 unique articles; some present data for more than one population and more than one treatment regimen)
General	1 [23]	86	2 [18, 24]	44–99	1 [25]	26	4
Case contacts	0	–	3 [26–28]	40–85	1 [25]	53	4
Healthcare workers	1 [19]	98	0	–	0	–	1
Homeless	0	–	2 [29, 30]	76–90	1 [25]	34	3
PWID	0	–	3 [31–33]	52–91	0	–	3
HIV infected	0	–	2 [34, 35]	90–92	1 [36]	91	3
Inmates	0	–	1 [37]	65	0	–	1
Immigrants	0	–	3 [38–40]	77–97	1 [25]	23	4
Patients with comorbidities	0	–	0	–	0	–	0
Retrospective studies (n = 25 unique articles; some present data for more than one population and more than one treatment regimen)
General	0	–	4 [89–92]	82–98	5 [16, 78, 93–95]	53–83	9
Case contacts	0	–	1 [96]	81	5 [13, 78, 97–99]	74–95	6
Healthcare workers	0	–	1 [100]	92	4 [78, 94, 101, 102]	47–89	5
Homeless	0	–	0	–	0	–	0
PWID	0	–	1 [103]	56	0	–	1
HIV infected	0	–	1 [104]	67	0	–	1
Inmates	0	–	0	–	2 [80, 105]	7–90	2
Immigrants	0	–	2 [106, 107]	78–84	3 [16, 93, 94]	57–82	5
Patients with comorbidities	1 [108]	93	1 [109]	82	0	–	2
Completion rates
Prospective studies (n = 39 unique articles; some present data for more than one population and more than one treatment regimen)
General	10 [12, 23, 25, 41, 42, 46, 47, 49, 50, 60]	61–95	10 [12, 18, 24, 25, 41, 42, 46, 47, 50, 57]	46–76	0	–	13
Case contacts	2 [51, 52]	71–82	4 [26, 27, 51, 52]	53–73	2 [12, 25]	60–64	6
Healthcare workers	0	–	1 [18]	44	0	–	1
Homeless	1 [60]	71	2 [18, 30]	25–33	1 [25]	44	4
PWID	0	–	4 [31, 32, 56, 58]	38–89	0	–	4
HIV infected	6 [36, 44, 48]	62–95	8 [18, 34–36, 44, 48, 54, 55]	55–89	0	–	8
Inmates	1 [53]	48	3 [37, 53, 62]	4–38	0	–	3
Immigrants	2 [43, 59]	72–80	8 [38–40, 43, 45, 57]	7–83	2 [12, 25]	61–79	9
Patients with comorbidities	1 [61]	87	0	–	0	–	1
Retrospective studies (n = 44 unique articles; some present data for more than one population and more than one treatment regimen)
General	14 [14–17, 65–67, 78, 79, 81–83, 110, 111]	56–93	23 [14–16, 64–67, 78, 79, 81–83, 89–92, 112–118]	39–96	1 [93]	54	27
Case contacts	3 [13, 14, 17]	63–69	4 [13, 14, 113, 116]	56–78	5 [78, 82, 97, 98, 119]	48–81	10
Healthcare workers	0	–	2 [100, 113]	17–75	3 [15, 78, 101]	40–79	5
Homeless	1 [120]	44	1 [64]	23	0	–	2
PWID	0	–	1 [103]	55	0	–	1
HIV infected	0	–	2 [14, 104]	55–66	0	–	2
Inmates	4 [80, 120]	48–100	2 [80, 121]	23–68	0	–	3
Immigrants	4 [14, 16, 17, 122]	60–85	11 [14, 16, 64, 89, 91, 92, 106, 113, 116, 123, 124]	38–86	5 [15, 65, 79, 82, 93]	53–69	18
Patients with comorbidities	1 [108]	92	1 [125]	75	0	–	2

HIV human immunodeficiency virus, n number of included studies, N total number of included studies, PWID people who inject drugs

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