Table 6 Risk factors for unresolved late-appearing anaemia after 2 weeks of starting treatment of uncomplicated falciparum malaria with artemether-lumefantrine, artesunate-amodiaquine or dihydroartemisinin-piperaquine showing the crude and adjusted odds ratio (OR) and the 95 % confidence interval (CI)

Gender

 Male

47

16

1

 Female

37

12

0.9(0.4–2.3)

1.00

-

-

Age (years)

  ≥ 3

65

20

1

  < 3

19

8

1.6(0.6–4.7)

0.52

-

-

Haematocrit at presentation (day 0)

  ≥ 25 %

65

20

1

  < 25 %

19

8

1.6(0.6–4.7)

0.52

-

-

Parasitaemia (μL⁻¹)

  ≤ 50,000

34

13

1

  > 50,000

50

15

0.7(0.3–1.7)

0.58

Parasite reduction ratio on day 1

  > 10⁴

57

14

1

1

  ≤ 10⁴

27

14

3.3 (1.3–8.7)

0.026

2.9 (1. −8.5)

0.05

Fever clearance time

  ≤ 1 day

75

25

1

  > 1 day

9

3

1.0(0.2–4.3)

1.00

Time of occurrence of late-appearing anaemia

  ≤ 28 days

62

13

1

1

  > 28 days

22

15

8.1(2.7–22.9)

0.0002

7.5(2.5–22.9)

<0.0001